N-((S)-1-Formyl-4-guanidino-butyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-((S)-1-Formyl-4-guanidino-butyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide
• 英文别名: 2-[(3S)-3-(benzylsulfonylamino)-2-oxopiperidin-1-yl]-N-[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]acetamide
• 化学式: C₂₀H₃₀N₆O₅S
• 分子量: 466.561
• InChiKey: WZYFZDIYCCGIQM-IRXDYDNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  185
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  FMOC-(3S)-3-1-羧甲基-2-戊内酰胺 、 alkaline earth salt of/the/ methylsulfuric acid 以50%的产率得到N-((S)-1-Formyl-4-guanidino-butyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide
  参考文献：
  名称：

  Novel Hydrazino-Carbonyl-Amino- Methylated Polystyrene (HCAM) Resin Methodology for the Synthesis of P₁-Aldehyde Protease Inhibitor Candidates

  摘要：

  [GRAPHICS]A new strategy for the synthesis of peptidyl and peptidomimetic P-1-aldehydes 3 on HCAM solid support is described. The appropriate C-terminal aldehyde precursors were prepared and anchored to a resin support via a semicarbazone linkage (HCAM resin). After synthetic elaboration, acidic hydrolysis efficiently delivered C-terminal target aldehydes 3a-h in good overall yields and in excellent purity.

  DOI：

  10.1021/ol991161e