N-[(R)-1-{[Acetyl-(2-methoxy-benzyl)-amino]-methyl}-2-(1H-indol-3-yl)-ethyl]-2-(4-cyclohexyl-piperazin-1-yl)-acetamide | 170567-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-[(R)-1-{[Acetyl-(2-methoxy-benzyl)-amino]-methyl}-2-(1H-indol-3-yl)-ethyl]-2-(4-cyclohexyl-piperazin-1-yl)-acetamide
• 英文别名: N-[(2R)-1-[acetyl-[(2-methoxyphenyl)methyl]amino]-3-(1H-indol-3-yl)propan-2-yl]-2-(4-cyclohexylpiperazin-1-yl)acetamide
• CAS: 170567-08-5
• 化学式: C₃₃H₄₅N₅O₃
• 分子量: 559.7
• InChiKey: HCKQHXNWJMHBJT-MUUNZHRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  80.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 2-Acylaminopropanamines as growth hormone secretagogues
  申请人：ELI LILLY AND COMPANY

  公开号：EP0761219A1

  公开（公告）日：1997-03-12

  This invention provides a series of substituted propanamines which are useful in treating a physiological condition which may be modulated by an increase in growth hormone. This invention also provides methods for the treatment of such physiological conditions which comprise administering a growth hormone secretagogue as described in the present invention in combination with growth hormone releasing hormone.

  本发明提供了一系列取代的丙胺胺，这些化合物在治疗可通过增加生长激素调节的生理状况方面具有用途。本发明还提供了治疗此类生理状况的方法，包括将本发明所述的生长激素促泌素与生长激素释放激素联合给药。
• Use of tachykinin antagonists in combination with serotonin agonists or serotonin reuptake inhibitors for the manufacture of a medicament for the treatment of allergic rhinitis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0747049A1

  公开（公告）日：1996-12-11

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a combination of a tachykinin receptor antagonist and either a serotonin agonist or a selective serotonin reuptake inhibitor. This administration may be concurrent or sequential, with either of the two activities being administered first.

  这项发明提供了治疗普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种缓释肽受体拮抗剂和5-羟色胺激动剂或选择性5-羟色胺再摄取抑制剂的组合。这种给药可以同时进行或顺序进行，两种活性中的任何一种都可以首先给予。
• Heterocyclic tachykinin receptor antagonists
  申请人：ELI LILLY AND COMPANY

  公开号：EP0693489A1

  公开（公告）日：1996-01-24

  This invention provides the novel compound of the following formula having the chemical name (R)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-(piperidin-1-yl)piperidin-1-yl)acetyl)amino]propane dihydrochloride trihydrate.

  本发明提供了化学名称为(R)-3-(1H-吲哚-3-基)-1-[N-(2-甲氧基苄基)乙酰氨基]-2-[N-(2-(4-(哌啶-1-基)哌啶-1-基)乙酰)氨基]丙烷二盐酸盐三水合物的下式新型化合物。
• Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine
  申请人：ELI LILLY AND COMPANY

  公开号：EP0710479A1

  公开（公告）日：1996-05-08

  This invention provides methods for the treatment or prevention of migraines which comprises administering to a mammal in need thereof a combination of a tachykinin receptor antagonist and a serotonin agonist. This administration may be concurrent or sequential, with either of the two activities being administered fi rst.

  本发明提供了治疗或预防偏头痛的方法，其中包括向有需要的哺乳动物施用速激肽受体拮抗剂和血清素激动剂的组合。这种给药可以是同时给药，也可以是按顺序给药，首先给药的是两种活性物质中的任何一种。
• Use of tachykinin receptors antagonists for the treatment of cold and allergic rhinitis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0747055A2

  公开（公告）日：1996-12-11

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a compound having activity as a tachykinin receptor antagonist.

  本发明提供了治疗或改善普通感冒或过敏性鼻炎症状的方法，包括向有需要的哺乳动物施用具有速激肽受体拮抗剂活性的化合物。