2-(2-(3,5-dimethylphenyl)-3-{2-[(2-nitro-1-{[2-(4-pyridinyl)ethyl]amino}ethenyl)amino]ethyl}-1H-indol-5-yl)-N,N-diethyl-2-methylpropanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(2-(3,5-dimethylphenyl)-3-{2-[(2-nitro-1-{[2-(4-pyridinyl)ethyl]amino}ethenyl)amino]ethyl}-1H-indol-5-yl)-N,N-diethyl-2-methylpropanamide
• 英文别名: 2-[2-(3,5-dimethylphenyl)-3-[2-[[(E)-2-nitro-1-(2-pyridin-4-ylethylamino)ethenyl]amino]ethyl]-1H-indol-5-yl]-N,N-diethyl-2-methylpropanamide
• 化学式: C₃₅H₄₄N₆O₃
• 分子量: 596.773
• InChiKey: ZEZLHUBGMHBCFI-AWSUPERCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  44
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• INDOLE DERIVATIVES AND THEIR USE AS GNRH ANTAGONISTS
  申请人：AstraZeneca AB

  公开号：EP1363903A1

  公开（公告）日：2003-11-26
• Compounds
  申请人：AstraZeneca AB

  公开号：US20030171354A1

  公开（公告）日：2003-09-11

  The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicament, a method of therapeutic treatment using such a compound and processes for producing the compounds. 1
• US6809098B2
  申请人：——

  公开号：US6809098B2

  公开（公告）日：2004-10-26
• [EN] INDOLE DERIVATIVES AND THEIR USE AS GNRH ANTAGONISTS<br/>[FR] DERIVES INDOLE ET LEUR UTILISATION EN TANT QU'ANTAGONISTES DE GNRH
  申请人：ASTRAZENECA AB

  公开号：WO2002066459A1

  公开（公告）日：2002-08-29

  The present invention relates to compounds of formula (I) which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicament, a method of therapeutic treatment using such a compound and processes for producing the compounds.