2-Amino-5-(diaminomethylideneamino)pentanoic acid;2,3-dihydroxybutanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-5-(diaminomethylideneamino)pentanoic acid;2,3-dihydroxybutanedioic acid
• 化学式: C10H20N4O8
• 分子量: 324.29
• InChiKey: ZCVVFWJFQMSYBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.67
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  243
• 氢给体数：
  8
• 氢受体数：
  10

文献信息

• Apo2 ligand/TRAIL formulations
  申请人：Genentech, Inc.

  公开号：EP2322165A1

  公开（公告）日：2011-05-18

  The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.

  本发明包括载脂蛋白 2L/TRAIL制剂和使用这种制剂的方法。本发明提供了稳定且具有更好的 Apo2L/TRAIL 三聚体形成的 Apo2L/TRAIL 冻干和晶体制剂。还提供了制造 Apo-2L/TRAIL 制剂的方法，以及含有此类制剂的设备和试剂盒。
• Apo-2 ligand/trail formulations
  申请人：Flores Heather

  公开号：US20050020498A1

  公开（公告）日：2005-01-27

  The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.

  本发明包括载脂蛋白 2L/TRAIL制剂和使用这种制剂的方法。本发明提供了稳定且具有更好的 Apo2L/TRAIL 三聚体形成的 Apo2L/TRAIL 冻干和晶体制剂。还提供了制造 Apo-2L/TRAIL 制剂的方法，以及含有此类制剂的设备和试剂盒。
• Apo2 ligand/trail formulations
  申请人：Lin P. Tanya

  公开号：US20050080006A1

  公开（公告）日：2005-04-14

  The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.

  本发明包括载脂蛋白 2L/TRAIL制剂和使用这种制剂的方法。本发明提供了稳定且具有更好的 Apo2L/TRAIL 三聚体形成的 Apo2L/TRAIL 冻干和晶体制剂。还提供了制造 Apo-2L/TRAIL 制剂的方法，以及含有此类制剂的设备和试剂盒。
• APO2 LIGAND/TRAIL FORMULATIONS
  申请人：GENENTECH, INC.

  公开号：EP1450847A2

  公开（公告）日：2004-09-01
• EP1450847A4
  申请人：——

  公开号：EP1450847A4

  公开（公告）日：2007-08-29