N-(4-fluoro-3-methylphenyl)-7-methoxy-8-propan-2-yl-5,8-dihydroquinazolin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(4-fluoro-3-methylphenyl)-7-methoxy-8-propan-2-yl-5,8-dihydroquinazolin-2-amine
• 化学式: C₁₉H₂₂FN₃O
• 分子量: 327.4
• InChiKey: XVNVTAZQLVCXCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1235815A1

  公开（公告）日：2002-09-04
• US6982260B1
  申请人：——

  公开号：US6982260B1

  公开（公告）日：2006-01-03
• [EN] QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES<br/>[FR] QUINAZOLINES ET LEUR UTILISATION DANS L'INHIBITION DES ENZYMES KINASE DEPENDANT DE LA CYCLINE
  申请人：WARNER LAMBERT CO

  公开号：WO2001038315A1

  公开（公告）日：2001-05-31

  This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discovered a group of 2-arylamino-quinazolines (I) and (II) that are potent inhibitors of cyclin-dependent kinases (cdks). The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention also provides pharmaceutical formulations comprising at least one of the quinazoline compounds together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. The invention further provides useful intermediates generated during the production of the quinazoline compounds.