(3S)-6-(benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3S)-6-(benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine
• 化学式: C₁₈H₁₈N₂O₂S
• 分子量: 326.4
• InChiKey: GGGUCGXTROTHDZ-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  84.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Arylsulphonyl substituted-tetrahydro- and hexahydro-carbazoles
  申请人：——

  公开号：US20030100596A1

  公开（公告）日：2003-05-29

  The invention provides compounds of formula I for use in treating conditions in which 5-HT 6 receptors are involved such as in anxiety, depression, schizophrenia, Alzheimer's disease, stress-related disease, panic, a phobia, obsessive compulsive disorder, obesity, post-traumatic stress syndrome, epilepsy, and other CNS disorders. 1

  该发明提供了公式I的化合物，用于治疗与5-HT6受体有关的疾病，如焦虑、抑郁症、精神分裂症、阿尔茨海默病、与压力相关的疾病、恐慌、恐惧症、强迫症、肥胖症、创伤后应激综合征、癫痫等中枢神经系统疾病。
• Arylsulphonyl substituted-tetrahydro-and hexahydro-carbazoles
  申请人：Pharmacia & Upjohn Company

  公开号：US20040162332A1

  公开（公告）日：2004-08-19

  The invention provides compounds of formula I for use in treating conditions in which 5-HT 6 receptors are involved such as in anxiety, depression, schizophrenia, Alzheimer's disease, stress-related disease, panic, a phobia, obsessive compulsive disorder, obesity, post-traumatic stress syndrome, epilepsy, and other CNS disorders. 1

  该发明提供了I式化合物，用于治疗与5-HT6受体有关的疾病，如焦虑、抑郁症、精神分裂症、阿尔茨海默病、与压力相关的疾病、惊恐、恐惧症、强迫症、肥胖症、创伤后应激综合症、癫痫和其他中枢神经系统疾病。1
• ARYLSULPHONYL-SUBSTITUTED TETRAHYDRO- AND HEXAHYDRO-CARBAZOLES AS 5-HT-6 RECEPTOR LIGANDS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1434578A1

  公开（公告）日：2004-07-07
• US6727274B2
  申请人：——

  公开号：US6727274B2

  公开（公告）日：2004-04-27
• [EN] ARYLSULPHONYL-SUBSTITUTED TETRAHYDRO- AND HEXAHYDRO-CARBAZOLES AS 5-HT-6 RECEPTOR LIGANDS<br/>[FR] CARBAZOLES ARYLSULFONYL TETRAHYDRO ET HEXAHYDRO SUBSTITUES UTILES COMME LIGANDS DU RECEPTEUR 5-HT-6
  申请人：UPJOHN CO

  公开号：WO2003030901A1

  公开（公告）日：2003-04-17

  The invention provides compounds of Formula (I) for use in treating conditions in which 5-HT6 receptors are involved such as in anxiety, depression, schizophrenia, Alzheimer's disease, stress-related disease, panic, a phobia, obsessive compulsive disorder, obesity, post-traumatic stress syndrome, epilepsy, and other CNS disorders, Formula (I), wherein [b] is a single or double bond and R1, R2, R3, R4, R5, R6, R7, X, Y and Z have any definition discussed herein.