8-ethyl-5-phenyl-6-7-8-9-tetrahydro-1H-pyrrolo-[3,2-h]-isoquinoline-2,3-dione-3-oxim | 309711-59-9

• 物质功能分类: 生物化工 - 抑制剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 8-ethyl-5-phenyl-6-7-8-9-tetrahydro-1H-pyrrolo-[3,2-h]-isoquinoline-2,3-dione-3-oxim
• 英文别名: 5-phenyl-6,7,8,9-tetrahydro-3-(hydroxyimino)-8-ethyl-1H-pyrrolo[3,2-h]isoquinoline-2(3H)-one；8-ethyl-3-(hydroxyamino)-5-phenyl-7,9-dihydro-6H-pyrrolo[3,2-h]isoquinolin-2-one
• CAS: 309711-59-9
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: CHVQAXYXYIDNDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  64.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
  申请人：——

  公开号：US20020058663A1

  公开（公告）日：2002-05-16

  This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment or aleviation of diseases or disorders associated with, or mediated by a drop in extracellular pH.

  本发明涉及使用能够抑制质子门控阳离子通道活性的化合物来治疗或缓解与细胞外pH下降相关或介导的疾病或障碍。
• COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
  申请人：Vohra Rahul

  公开号：US20090246134A1

  公开（公告）日：2009-10-01

  The present invention is directed toward radiolabelled ASIC imaging agents, as well as metabolites of ASIC antagonists. These compounds are useful for the diagnosis and treatment of diseases and disorders related to the activity of gated ion channels.

  本发明涉及放射性标记的ASIC成像试剂，以及ASIC拮抗剂的代谢物。这些化合物对于诊断和治疗与门控离子通道活性相关的疾病和障碍非常有用。
• Compositions and methods for modulating gated ion channels
  申请人：Vohra Rahul

  公开号：US20080004272A1

  公开（公告）日：2008-01-03

  The present invention relates to compositions and methods to modulate the activity of gated ion channels.

  本发明涉及用于调节门控离子通道活性的组合物和方法。
• PYRROLO [3, 4-h] ISOQUINOLINE COMPOUNDS AND METHODS FOR MODULATING GATED ION CHANNELS
  申请人：VOHRA Rahul

  公开号：US20100197721A1

  公开（公告）日：2010-08-05

  The present invention relates to compositions and methods to modulate the activity of gated ion channels.

  本发明涉及组合物和方法，用于调节门控离子通道的活性。
• INHIBITORS OF PROTON-GATED CATION CHANNELS AND THEIR USE IN THE TREATMENT OF ISCHAEMIC DISORDERS
  申请人：NEUROSEARCH A/S

  公开号：EP1183025A2

  公开（公告）日：2002-03-06