[(2R,3S,6S,7R,8R)-3-[(3-ormamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 2-methylbutanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R,3S,6S,7R,8R)-3-[(3-ormamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 2-methylbutanoate
• 英文别名: [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 2-methylbutanoate
• 化学式: C₂₈H₄₀N₂O₉
• 分子量: 548.6
• InChiKey: UPHOMQADKXDOFD-ORBKLCBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Mitochondrial inhibitors for use in culturing pluripotent stem cells
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10196604B2

  公开（公告）日：2019-02-05

  Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compounds, such as substituted 5-aminotetrazoles, which are reversible mitochondrial inhibitors. The pluripotency of the stem cells after culture is verified by the overexpression of pluripotent stem cell markers, exemplified by at least one of the genes NANOG, OCT4, and SURVIVIN after periods of culture in ambient oxygen.

  已公开的某些杂环有机化合物可抑制线粒体呼吸，还能使培养中的人类胚胎干细胞保持多能性，即使在有氧的情况下也是如此。例如，取代的 5-氨基四唑化合物是可逆的线粒体抑制剂。培养后干细胞的多能性通过多能干细胞标志物的过度表达来验证，例如，在环境氧气中培养一段时间后，多能干细胞标志物中至少有一种基因NANOG、OCT4和SURVIVIN。
• MITOCHONDRIAL INHIBITORS FOR USE IN CULTURING PLURIPOTENT STEM CELLS
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20170130198A1

  公开（公告）日：2017-05-11

  Disclosed are certain heterocyclic organic compounds that inhibit mitochondrial respiration and also lead to the maintenance of pluripotency of human embryonic stem cells in culture, even in the presence of oxygen. Exemplified are compounds, such as substituted 5-aminotetrazoles, which are reversible mitochondrial inhibitors. The pluripotency of the stem cells after culture is verified by the overexpression of pluripotent stem cell markers, exemplified by at least one of the genes NANOG, OCT4, and SURVIVIN after periods of culture in ambient oxygen.