(3Z)-3-(1H-imidazol-5-ylmethylidene)-5-pyridin-3-yl-1H-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3Z)-3-(1H-imidazol-5-ylmethylidene)-5-pyridin-3-yl-1H-indol-2-one
• 化学式: C₁₇H₁₂N₄O
• 分子量: 288.3
• InChiKey: CKQPXVDVVKKPGF-CHHVJCJISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Oxindoles which are inhibitors of CDK-1 and their application in therapeutics
  申请人：AVENTIS PHARMA SA

  公开号：US20040110770A1

  公开（公告）日：2004-06-10

  The present invention relates to a compound of formula (I): 1 wherein R5 is selected from the group consisting of 3-pyridyl, 5-pyrimidinyl, —CONH—(C 1 -C 4 alkyl), —NHCO—(C 1 -C 4 alkyl), halogen, —SO 2 NH 2 , —NO 2 , —CF 3 or thien-2-ylcarbonyl 2 and —CO 2 R where R can be hydrogen or C 1 -C 4 alkyl; and Ar is selected from the group consisting of 5-imidazolyl, 2-pyrrolyl optionally substituted by a C 1 -C 4 alkyl radical, 2-furyl or 2-thiazolyl, in the E or Z geometrical isomeric form or a mixture of the two geometrical isomeric forms. The invention is also directed to a method of treating primary and secondary tumours in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound of formula I. The invention is also directed to a method of using a compound of formula I to treat cancer, inhibit the proliferation of a cell and induce cell apoptosis, comprising contacting a cell with an effective amount of the compound of formula I., The invention is also directed to a method of preparing the compound of formula I.

  本发明涉及一种式为(I)的化合物：其中R5选自3-吡啶基，5-嘧啶基，-CONH-(C1-C4烷基)，-NHCO-(C1-C4烷基)，卤素，-SO2NH2，-NO2，-CF3或噻吩-2-基酰基2和-CO2R，其中R可以是氢或C1-C4烷基；Ar选自5-咪唑基，2-吡咯基（可选择由C1-C4烷基基团取代），2-呋喃基或2-噻唑基，在E或Z几何异构体形式或两种几何异构体形式的混合物中。 本发明还涉及一种治疗患有原发性和继发性肿瘤的患者的方法，包括向患者投予式为I的化合物的治疗有效量。本发明还涉及一种使用式为I的化合物治疗癌症、抑制细胞增殖和诱导细胞凋亡的方法，包括用式为I的化合物的有效量与细胞接触。本发明还涉及一种制备式为I的化合物的方法。
• OXINDOLES INHIBITEURS DE CDK-1 ET LEUR APPLICATION EN THERAPEUTIQUE
  申请人：Aventis Pharma S.A.

  公开号：EP1366038B1

  公开（公告）日：2005-08-31