2,2-diphenyl-thiolane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-diphenyl-thiolane
• 英文别名: Diphenyltetrahydrothiophene；2,2-diphenylthiolane
• 化学式: C₁₆H₁₆S
• 分子量: 240.369
• InChiKey: CRONHQHPBCSFCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二苯基甲烷硫酮 、 1,3-二溴丙烷 在 氢化镱 作用下， 反应 3.0h， 以74%的产率得到2,2-diphenyl-thiolane
  参考文献：
  名称：

  Ytterbium Metal Mediated Desulfurization and Coupling Reaction of Diaryl Thioketones

  摘要：

  二芳基硫酮可选择性地通过镱金属还原为二芳基甲硫醇、二芳基甲烷或四芳基乙烯，这一过程涉及硫金属中间体，在硫羰基的碳和硫原子处发生亲电子偶联反应。

  DOI：

  10.1246/cl.1994.611

文献信息

• Ytterbium Metal Mediated Desulfurization and Coupling Reaction of Diaryl Thioketones
  作者：Yoshikazu Makioka、Shin-ya Uebori、Masumi Tsuno、Yuki Taniguchi、Ken Takaki、Yuzo Fujiwara

  DOI：10.1246/cl.1994.611

  日期：1994.3

  Diaryl thioketones are selectively reduced with ytterbium metal to diarylmethanethiols, diarylmethanes or tetraarylethylenes, via thiometallacycle intermediates which undergo electrophilic coupling at thiocarbonyl carbon and sulfur.

  二芳基硫酮可选择性地通过镱金属还原为二芳基甲硫醇、二芳基甲烷或四芳基乙烯，这一过程涉及硫金属中间体，在硫羰基的碳和硫原子处发生亲电子偶联反应。
• Process for the Preparation of (Aminoalkylamino)Alkyl Halides and Conversion to Amifostine
  申请人：Samsel Edward G.

  公开号：US20080275265A1

  公开（公告）日：2008-11-06

  The present invention relates to processes for the preparation of (ω-aminoalkylamino)alkyl halides, their conversion to S-ω-(ω-aminoalkylamino)alkyl phosphothioates, and purification of the crystalline products of the reaction. The preparation process for the (ω-aminoalkylamino)alkyl halides comprises contacting an appropriate alcohol with a brominating agent in the presence of a sulfone solvent under temperature and pressure conditions suitable to effect salt formation without subsequent premature precipitation. The process is especially useful for converting (ω-aminoalkylamino)ethyl alcohol to amifostine.

  本发明涉及制备(ω-氨基烷基氨基)烷基卤化物的过程，以及它们转化为S-ω-(ω-氨基烷基氨基)烷基磷酰硫酸酯，并纯化反应的晶体产物。制备(ω-氨基烷基氨基)烷基卤化物的过程包括在磺醇溶剂存在下，在适当的温度和压力条件下，将适当的醇与溴化剂接触以形成盐，而不会发生过早的沉淀。该过程特别适用于将(ω-氨基烷基氨基)乙醇转化为阿米福斯汀。
• ハロゲン化（ω−アミノアルキルアミノ）アルキルの製造およびアミホスチンへの転化の方法
  申请人：アルベマール・コーポレーシヨン

  公开号：JP2009514863A

  公开（公告）日：2009-04-09

  The present invention relates to the preparation of halogenated (ω-aminoalkylamino) alkyls, their conversion to S-ω- (ω-aminoalkylamino) alkylphosphothioates, and purification of the crystalline product of the reaction. Regarding the method. The process for the production of halogenated (ω-aminoalkylamino) alkyl is to contact a suitable alcohol with a brominating agent in the presence of a sulfone solvent under suitable temperature and pressure conditions to provide salt formation without subsequent precipitating. Comprising making. The method is particularly useful for converting (ω-aminoalkylamino) ethyl alcohol to amifostine.

  本发明涉及卤代（ω-氨基烷基氨基）烷基的制备，它们转化为S-ω-（ω-氨基烷基氨基）烷基磷酰硫酸酯，并纯化反应的结晶产物。关于该方法，制备卤代（ω-氨基烷基氨基）烷基的过程是将适当的醇与溴化剂在磺酰溶剂存在下，在适当的温度和压力条件下接触以提供盐形成，而不会随后沉淀。该方法特别适用于将（ω-氨基烷基氨基）乙醇转化为阿米托星。
• PROCESS FOR THE PRODUCTION OF POLYARYLENE SULFIDE RESINS
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：EP1550685A1

  公开（公告）日：2005-07-06

  The present invention is a process for the production of polyarylene sulfide based resin, wherein in washing a polyarylene sulfide based resin with a mixed solvent of an aprotic organic solvent and water in a softened or molten state, the polyarylene sulfide based resin partially dissolved in the washing liquid is recovered, to be specific, the polyarylene sulfide based resin dissolved in the washing liquid is precipitated, separated and recovered by cooling the washing liquid after washing and/or adding water to the washing liquid, and it is reused. According to the present invention, capable of being provided is a process for the production of polyarylene sulfide based resin in which the polyarylene sulfide based resin formed by polymerization is scarcely lost in washing the above resin with a solvent.

  本发明是一种生产聚芳基硫醚树脂的工艺，其中在用软化或熔融状态的烷基有机溶剂和水的混合溶剂洗涤聚芳基硫醚树脂时，回收部分溶解在洗涤液中的聚芳基硫醚树脂，具体而言，通过冷却洗涤后的洗涤液和/或向洗涤液中加水，沉淀、分离和回收溶解在洗涤液中的聚芳基硫醚树脂，并将其重复使用。根据本发明，能够提供一种生产聚芳硫醚基树脂的工艺，在该工艺中，通过聚合形成的聚芳硫醚基树脂在用溶剂洗涤上述树脂时几乎不会损失。
• PROCESS FOR THE PRODUCTION OF POLYARYLENE SULFIDE
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：EP1550686A1

  公开（公告）日：2005-07-06

  The production process of the present invention for polyarylene sulfide is characterized by that in a process for continuously producing polyarylene sulfide by reacting a sulfur source with a dihalogenated aromatic compound in an aprotic organic solvent, it comprises at least one polymerization reaction step in which two phases of a polymer phase and a solvent phase are separated and in which the polymer phase corresponding to a dispersion phase is a dispersion phase comprising globular droplets and that an end terminator is used in the above polymerization reaction step. According to the present invention, a polymer can be prevented from being adhered onto a polymerization reaction bath to thereby make it possible to discharge a polymer phase and a solvent phase from the polymerization bath in a constant proportion; resultingly, a PAS composition (concentration) in the polymerization bath can always be maintained at a constant value; and polyarylene sulfide having a raised and stabilized molecular weight can continuously be produced.

  本发明的聚芳基硫醚生产工艺的特点是，在通过硫源与二卤代芳香族化合物在非沸腾有机溶剂中反应连续生产聚芳基硫醚的工艺中，至少包括一个聚合反应步骤，在该步骤中，聚合物相和溶剂相两相分离，其中与分散相相对应的聚合物相是由球状液滴组成的分散相，并且在上述聚合反应步骤中使用了末端终止剂。根据本发明，可以防止聚合物附着在聚合反应槽上，从而使聚合物相和溶剂相能够以恒定的比例从聚合槽中排出；因此，聚合槽中的 PAS 成分（浓度）可以始终保持在恒定值；并且可以连续生产出分子量得到提高和稳定的聚芳基硫醚。