5-{(E)-(1S,5S,6R,-7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octan-3-ylidene}-pentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-{(E)-(1S,5S,6R,-7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octan-3-ylidene}-pentanoic acid
• 英文别名: (1S,2R,3R,5S)-7-[(E)-4-carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane；(5Z)-5-[5-hydroxy-4-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
• 化学式: C₂₂H₃₂O₄
• 分子量: 360.494
• InChiKey: HIFJCPQKFCZDDL-SYDUVVICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  四氢呋喃 、 吗啉 、 5-{(E)-(1S,5S,6R,-7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octan-3-ylidene}-pentanoic acid 、 N,N'-羰基二咪唑 在 ammonium chloride 、 sodium sulfate 作用下， 以 N-甲基乙酰胺 、 乙酸乙酯 为溶剂， 以40%的产率得到(1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane
  参考文献：
  名称：

  NEUROPATHY IMPROVERS CONTAINING NITROGENOUS COMPOUNDS AS THE ACTIVE INGREDIENT

  摘要：

  公开号：

  EP1201235B1

文献信息

• Organo-Soluble Chitosan Salts and Chitosan-Derived Biomaterials Prepared Thereof
  申请人：Chu Chih-Chang

  公开号：US20110150999A1

  公开（公告）日：2011-06-23

  Organo-soluble chitosan salts, method for preparing organo-soluble salts, chitosan-derived materials prepared with organo-soluble chitosan salts, and methods for preparing chitosan-derived materials are disclosed.

  本发明涉及可溶于有机溶剂的壳聚糖盐，制备可溶于有机溶剂的盐的方法，用可溶于有机溶剂的壳聚糖盐制备的壳聚糖衍生材料，以及制备壳聚糖衍生材料的方法。
• Bioactive stents and methods for use thereof
  申请人：MediVas, LLC

  公开号：US20040170685A1

  公开（公告）日：2004-09-02

  The present invention is based on the discovery that stents can be coated with biodegradable, bioactive polymers that promote endogenous healing processes at a site of stent implantation. The polymers biodegrade over time, releasing agents which establish or re-establish the natural healing process in an artery. Preferably, the stent is implanted at the time an artery is damaged, such at the time of angioplasty to protect the damaged artery against deleterious blood-borne factors that initiate proliferation of smooth muscle cells.

  本发明的基础是发现支架上可以涂覆可生物降解的生物活性聚合物，这种聚合物可以促进支架植入部位的内源性愈合过程。 随着时间的推移，聚合物会发生生物降解，释放出能够建立或重建动脉自然愈合过程的物质。 支架最好在动脉受损时植入，例如在血管成形术时植入，以保护受损动脉免受血液中有害因子的影响，这些因子会导致平滑肌细胞增殖。
• Bioactive stents for type II diabetics and methods for use thereof
  申请人：Carpenter W. Kenneth

  公开号：US20050238689A1

  公开（公告）日：2005-10-27

  The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.

  本发明基于以下发现：在血管支架或其他植入式医疗设备上涂覆一种可生物降解的生物相容性聚合物，聚合物上附着一种生物配体，该生物配体可从循环血液中特异性捕获内皮细胞祖细胞（PECs），从而促进 II 型糖尿病患者健康内皮的内源性形成。在一个实施方案中，生物配体是一种能与 PECs 上的整合素受体特异性结合的多肽。本发明还提供了使用此类血管支架和其他植入装置促进 II 型糖尿病患者血管愈合的方法，例如在机械干预之后。
• Wound care polymer compositions and methods for use thereof
  申请人：Carpenter W. Kenneth

  公开号：US20060188486A1

  公开（公告）日：2006-08-24

  The present invention provides wound healing or wound care polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The compositiona can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are dispersed in a biodegradable polymer or hydrogel, or both. Methods of using the invention bioactive polymer compositions to deliver wound healing agents that promote natural healing of wounds, especially chronic wounds, are also provided.

  本发明提供了伤口愈合或伤口护理聚合物组合物，可通过调整组合物的各种成分，配制成以可控速率释放伤口愈合剂的组合物。该组合物a 可用于外部伤口敷料，也可用作聚合物植入物，将伤口愈合剂输送到身体内部部位，还可用作可植入手术器械表面的涂层，以输送分散在生物可降解聚合物或水凝胶中的伤口愈合剂，或两者兼而有之。本发明还提供了使用本发明生物活性聚合物组合物输送伤口愈合剂的方法，可促进伤口，尤其是慢性伤口的自然愈合。
• ELASTOMERIC FUNCTIONAL BIODEGRADABLE COPOLYESTER AMIDES AND COPOLYESTER URETHANES
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP1313794A2

  公开（公告）日：2003-05-28