5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,6-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,6-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine
• 英文别名: 5-chloro-6-(2,6-difluorophenyl)-7-(4-methyl-1-piperidinyl)[1,2,4]triazolo[1,5-a]pyrimidine；5-Chloro-6-(2,6-difluorophenyl)-7-(4-methylpiperidin-1-yl)-[1,2,4]-triazolo-[1,5-alpha]-pyrimidine；5-chloro-6-(2,6-difluorophenyl)-7-(4-methylpiperidin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine
• 化学式: C₁₇H₁₆ClF₂N₅
• 分子量: 363.797
• InChiKey: ORTLEUXFZUFBEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,6-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine 、 水 、 N,N-二甲基甲酰胺 在 氰化四乙基铵 甲基叔丁基醚 、 水 作用下， 反应 16.0h， 以to yield 6,95 g of the title compound of mp. 212° C.的产率得到6-(2,6-Difluorophenyl)-7-(4-methyl-1-piperidinyl)[1,2,4]triazolo[1,5-a]pyrimidine-5-carbonitrile
  参考文献：
  名称：

  6-(2,6-difluorophenyl)-triazolopyrimidines as fungicides

  摘要：

  公式（I）中的6-（2,6-二氟苯基）-三唑嘧啶，其中R1和R2独立表示氢或烷基，烷基，烯基，炔基或烯二烃基，环烷基，苯基，萘基或含有1至4个氮原子或1至3个氮原子和1个硫或氧原子的5-或6元杂环基，或含有1至4个氮原子或1至3个氮原子和1个硫或氧原子的5-或6元杂环芳基，其中R1和R2基团可以是未取代的或按定义在说明中被取代的，或R1和R2连同相邻的氮原子表示一个含有1至4个氮原子或1至3个氮原子和1个硫或氧原子的5-或6元杂环环，该环可以被取代；X是卤素，氰基，烷氧基，卤代烷氧基或烯基氧基；制备它们的方法，包含它们的组合物以及它们用于对抗植物病原真菌的用途。1

  公开号：

  US20040162428A1

文献信息

• Substituted-triazolopyrimidines as anticancer agents
  申请人：American Home Products Corporation

  公开号：US20020068744A1

  公开（公告）日：2002-06-06

  The invention provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

  该发明提供了一种治疗或抑制哺乳动物体内癌症肿瘤细胞及相关疾病的方法，包括向该哺乳动物体内施用有效量的取代三唑吡啶衍生物或其药学上可接受的盐，并进一步提供了一种通过与微管蛋白和微管相互作用并促进微管聚合的方法，治疗或抑制哺乳动物体内癌症肿瘤细胞及相关疾病，包括向该哺乳动物体内施用有效量的取代三唑吡啶衍生物或其药学上可接受的盐。
• SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS
  申请人：Wyeth

  公开号：EP1307200A2

  公开（公告）日：2003-05-07
• Fungicidal mixtures for controlling rice pathogens
  申请人：Blasco Tormo i Jordi

  公开号：US20070071833A1

  公开（公告）日：2007-03-29

  Fungicidal mixtures for controlling rice pathogens, which mixtures comprise, as active components, 1) the triazolopyrimidine derivative of the formula I, and 2) sulfur (II), in a synergistically effective amount, methods for controlling rice pathogens using mix-tures of the compound I with sulfur (II), the use of the compound I with sulfur (II) for preparing such mixtures and compositions comprising these mixtures are described.
• US7329663B2
  申请人：——

  公开号：US7329663B2

  公开（公告）日：2008-02-12
• [EN] SUBSTITUTED-TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS<br/>[FR] TRIAZOLOPYRIMIDINES SUBSTITUES COMME AGENTS ANTICANCEREUX
  申请人：AMERICAN HOME PROD

  公开号：WO2002002563A2

  公开（公告）日：2002-01-10

  The invention provides a method of treating of inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.