N-(3,4-Dichlorobenzyl)-4-(2-hydroxyethoxy)indole-2-carboxylic Acid | 287481-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(3,4-Dichlorobenzyl)-4-(2-hydroxyethoxy)indole-2-carboxylic Acid
• 英文别名: 1-[(3,4-Dichlorophenyl)methyl]-4-(2-hydroxyethoxy)indole-2-carboxylic acid
• CAS: 287481-97-4
• 化学式: C₁₈H₁₅Cl₂NO₄
• 分子量: 380.227
• InChiKey: ZNLBYHFHZCVVRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  71.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ANTI-IMFLAMMATORY INDOLE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1150954A1

  公开（公告）日：2001-11-07
• US6569888B1
  申请人：——

  公开号：US6569888B1

  公开（公告）日：2003-05-27
• [EN] ANTI-INFLAMMATORY INDOLE DERIVATIVES<br/>[FR] DERIVES D'INDOLE, ANTI-INFLAMMATOIRES
  申请人：ASTRAZENECA US LIMITED

  公开号：WO2000046198A1

  公开（公告）日：2000-08-10

  Compounds of formula (I) or a pharmaceutically acceptable salt, in vivo hydrolysable ester, or amide thereof, where X is CH2 or SO2; R1 is an optionally substituted aryl or heteroaryl ring; R4 is a group OR15 or S(O)¿qR?15, where q is 0, 1 or 2 and R15 is a substituted hydrogen-containing alkyl group; and R?2, R3, R5, R6 and R7¿ are specified organic groups. These compounds are useful in therapy, in particular of inflammatory disease, and methods of producing them as well as pharmaceutical compositions containing them are also described and claimed.