2-[1-(aminomethyl)cyclohexyl]acetic acid;(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[1-(aminomethyl)cyclohexyl]acetic acid;(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
• 化学式: C23H31NO5
• 分子量: 401.5
• InChiKey: WVIMSSROHUIPPV-FVGYRXGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.41
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• ANALGESIC COMPOSITIONS COMPRISING ANTI-EPILEPTIC COMPOUNDS AND METHODS OF USING SAME
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1161263A1

  公开（公告）日：2001-12-12
• [EN] ANALGESIC COMPOSITIONS COMPRISING ANTI-EPILEPTIC COMPOUNDS AND METHODS OF USING SAME<br/>[FR] COMPOSITIONS ANALGESIQUES COMPRENANT DES COMPOSES ANTI-EPILEPTIQUES, ET LEURS PROCEDES D'UTILISATION
  申请人：WARNER LAMBERT CO

  公开号：WO2000053225A1

  公开（公告）日：2000-09-14

  The present invention is directed to novel combinations of one or more anti-epileptic compounds that demonstrate pain alleviating properties, with one or more compounds selected from the group consisting of analgesics, NMDA receptor antagonists, NSAIDs, and combinations thereof, and pharmaceutical compositions comprising same. It has been discovered that the administration of anti-epileptic compounds that demostrates pain alleviating properties in these novel combinations results in an improved reduction in the frequency and severity of pain. It is also believed that the incidence of unwanted side effects can be reduced by these novel combinations in comparison to using higher doses of a single agent treatment to achieve a similar therapeutic effect. The present invention is also directed to methods of using effective amounts of the novel pharmaceutical compositions to treat pain in mammals.