N-2-benzothiazolyl-3,4-dihydrobenzothieno[2,3-c]pyridine-2(1H)-butanamine | 263543-68-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-2-benzothiazolyl-3,4-dihydrobenzothieno[2,3-c]pyridine-2(1H)-butanamine
• 英文别名: N-[4-(3,4-dihydro-1H-[1]benzothiolo[2,3-c]pyridin-2-yl)butyl]-1,3-benzothiazol-2-amine
• CAS: 263543-68-6
• 化学式: C₂₂H₂₃N₃S₂
• 分子量: 393.577
• InChiKey: GQFJWMBWXUSIDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  84.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• TRICYCLIC DELTA3-PIPERIDINES AS ALPHA2-ANTAGONISTS
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP1119571A2

  公开（公告）日：2001-08-01
• US6495555B1
  申请人：——

  公开号：US6495555B1

  公开（公告）日：2002-12-17
• [EN] TRICYCLIC DELTA 3-PIPERIDINES AS alpha 2-ANTAGONISTS<br/>[FR] PIPERIDINES DOLLAR G(D)-3 TRICYCLIQUES COMME ANTAGONISTES D' alpha -2
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2000020421A2

  公开（公告）日：2000-04-13

  The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; n is 1 or 2; X1 is -O-, -S-, -S(=O)- or -S(=O)2-; each R1 is independently hydrogen, halogen, C¿1-6?alkyl, nitro, hydroxy or C1-4alkyloxy; D is an optionally substituted mono, bi- or tricyclic nitrogen containing heterocycle, a 2H-benzopyranone, a benzamide, a benzophenone or a phenoxyphenyl having central α2-adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions.