1-[2-(5-hydroxy-1H-indol-3-yl)ethyl]pyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[2-(5-hydroxy-1H-indol-3-yl)ethyl]pyrrole-2,5-dione
• 化学式: C₁₄H₁₂N₂O₃
• 分子量: 256.26
• InChiKey: VMKYSRFQRSJROR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel ligands and methods for preparing same
  申请人：——

  公开号：US20010051348A1

  公开（公告）日：2001-12-13

  A process is disclosed for modifying a parent ligand by attaching to the parent ligand a conjugation agent that is reactive with a moiety of a target receptor to which the parent ligand binds such that a covalent bond is formable between the conjugation agent and the receptor moiety. Also disclosed are compositions, probes and methods of detecting and/or quantifying receptors using the modified ligands of the invention.

  本发明公开了一种对母体配体进行修饰的方法，即在母体配体上附着一种与母体配体所结合的目标受体的某一分子具有反应性的共轭制剂，从而使共轭制剂与受体分子之间形成共价键。还公开了使用本发明的修饰配体检测和/或量化受体的组合物、探针和方法。
• LIGAND CONJUGATES AND METHODS FOR PREPARING SAME
  申请人：NATIONAL UNIVERSITY OF SINGAPORE

  公开号：EP1289561A2

  公开（公告）日：2003-03-12
• US7153977B2
  申请人：——

  公开号：US7153977B2

  公开（公告）日：2006-12-26
• [EN] NOVEL LIGANDS AND METHODS FOR PREPARING SAME<br/>[FR] NOUVEAUX LIGANDS ET PROCEDES DE PREPARATION CORRESPONDANTS
  申请人：UNIV SINGAPORE

  公开号：WO2001054731A2

  公开（公告）日：2001-08-02

  A process is disclosed for modifying a parent ligand by attaching to the parent ligand a conjugation agent that is reactive with a moiety of a target receptor to which the parent ligand binds such that a covalent bond is formable between the conjugation agent and the receptor moiety. Also disclosed are compositions, probes and methods of detecting and/or quantifying receptors using the modified ligands of the invention.