4-(1H-indol-2-yl)benzene-1,3-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(1H-indol-2-yl)benzene-1,3-diamine
• 化学式: C₁₄H₁₃N₃
• 分子量: 223.27
• InChiKey: ILBKBRBXCXDCFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.8
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] ANTI-CANCER COMPOUNDS<br/>[FR] COMPOSÉS ANTI-CANCEREUX
  申请人：UNIV SYDNEY

  公开号：WO2016119017A1

  公开（公告）日：2016-08-04

  The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).

  本发明涉及新的药物代理，以及它们在治疗增殖性疾病（特别是脑癌）中的应用。
• [EN] SUBSTITUTED FLUORANTHENE-7-CARBONITRILES AS FLUORESCENT DYES FOR CELL IMAGING APPLICATIONS<br/>[FR] FLUORANTHÈNE-7-CARBONITRILES SUBSTITUÉS UTILISÉS EN TANT QUE COLORANTS FLUORESCENTS POUR DES APPLICATIONS D'IMAGERIE CELLULAIRE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014147642A1

  公开（公告）日：2014-09-25

  The present invention relates to novel donor-acceptor fluoranthenes of the general formula I which can be used potentially in developing fluorescent probes, and a process of preparing said novel compounds. More particularly, the present invention relates to amine or alkoxy group as donor and nitrile group as an acceptor attached to the fluoranthene skeleton, processes for preparing the said compounds and their uses as fluorescent probes in chemical and biological sciences such as cell imaging applications, diagnostics, fluorescent tags and other useful applications. The compounds are prepared by reacting 2H-pyran-2-ones in isolated or rigid conformations with cyclic ketones containing methylene carbonyl moiety in the presence of a base in an organic solvent.

  本发明涉及一种新型供体-受体氟蒽化合物，其通式为I，可能用于开发荧光探针，并提供了制备这些新型化合物的方法。更具体地说，本发明涉及将胺或烷氧基作为供体，将腈基作为受体连接到氟蒽骨架上，制备这些化合物的方法，以及它们在化学和生物科学中作为荧光探针的用途，如细胞成像应用、诊断、荧光标记和其他有用的应用。这些化合物是通过在有机溶剂中在孤立或刚性构象下，将2H-吡喃-2-酮与含有亚甲基羰基团的环状酮在碱存在下反应而制备的。
• Polymer-bound antibody cancer therapeutic agent
  申请人：Epstein L. Alan

  公开号：US20050214286A1

  公开（公告）日：2005-09-29

  Described is a cancer therapeutic agent comprising a polymer to which is linked three or more anti-tumor cell antibodies. Soluble polymers of between 6-8 Kd in size are preferred. The antibodies of the polymer can bind to a tumor cell antigen of a tumor cell and induce apoptosis or cell death of the tumor cell. The polymer may be linked to different antibodies to the same tumor antigen or to different tumor antigens. Methods of treating an individual with cancer using the cancer therapeutic agent are also described.

  本发明涉及一种癌症治疗剂，其包含一种聚合物，该聚合物与三个或更多的抗肿瘤细胞抗体连接。优选大小为6-8 Kd的可溶性聚合物。该聚合物的抗体可以结合肿瘤细胞的抗原，并诱导肿瘤细胞的凋亡或死亡。该聚合物可以与不同的抗体连接到同一种肿瘤抗原或不同的肿瘤抗原上。本发明还描述了使用该癌症治疗剂治疗患有癌症的个体的方法。
• Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications
  申请人：Vacanti P. Joseph

  公开号：US20060019326A1

  公开（公告）日：2006-01-26

  The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects, new uses) of existing drugs. Preferably, evaluation is carried out in three-dimensional tissue-engineered systems, wherein drug toxicity, metabolism, interaction and/or efficacy can be determined.

  本发明通常涉及组织工程、药物发现和药物开发领域的组合。更具体地提供了测试实验药物的功效和安全性、定义实验药物的代谢途径以及表征现有药物的属性（例如副作用、新用途）的新方法和材料。优选地，在三维组织工程系统中进行评估，可以确定药物毒性、代谢、相互作用和/或功效。
• Novel anti-HIV antibodies
  申请人：CIBA-GEIGY AG

  公开号：EP0519866A1

  公开（公告）日：1992-12-23

  The invention concerns monoclonal antibodies and antibody derivatives directed against HIV core protein p24 which recognize p24 expressed on the surface of HIV-infected macrophages and/or kill HIV-infected cells. The monoclonal antibodies of the invention may be murine antibodies or chimeric antibodies consisting of human constant regions and murine variable or hypervariable regions. Methods of manufacture of such antibodies, hybridoma or transfectoma cell lines secreting them and methods for production of the hybridoma or transfectoma cell lines are also encompassed by this invention. The invention further concerns recombinant DNA comprising an insert coding for the variable regions of antibodies against HIV core protein p24 having the mentioned properties, methods of manufacture of such recombinant DNAs, and host cells transformed with such recombinant DNAs. The antibodies are especially useful for the prevention of the progression of AIDS and for the treatment of AMS, but can also be used for the diagnosis of HIV infection in an immunoassay.

  本发明涉及针对艾滋病毒核心蛋白 p24 的单克隆抗体和抗体衍生物，它们能识别感染艾滋病毒的巨噬细胞表面表达的 p24 和/或杀死感染艾滋病毒的细胞。本发明的单克隆抗体可以是鼠抗体或由人类恒定区和鼠可变区或超可变区组成的嵌合抗体。本发明还包括制造这种抗体的方法、分泌这种抗体的杂交瘤或转染瘤细胞系以及生产杂交瘤或转染瘤细胞系的方法。本发明还涉及重组 DNA（包含编码具有上述特性的抗 HIV 核心蛋白 p24 抗体可变区的插入物）、制造这种重组 DNA 的方法以及用这种重组 DNA 转化的宿主细胞。 这种抗体特别适用于预防艾滋病的发展和治疗急性髓系白血病，也可用于免疫测定法诊断艾滋病病毒感染。