2-(furan-2-yl)-5-[2-(5-methylfuran-2-yl)ethyl]-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(furan-2-yl)-5-[2-(5-methylfuran-2-yl)ethyl]-1H-indole
• 化学式: C₁₉H₁₇NO₂
• 分子量: 291.3
• InChiKey: BAHNUMWKNPDDKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  42.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Interaction inhibitors of tcf-4 with beta-catenin
  申请人：——

  公开号：US20040204477A1

  公开（公告）日：2004-10-14

  A compound of formula (I) is provided which is able to interact with &bgr;-catenin/TCF-4 binding site, having a structure essentially equivalent to a pharmacophore (IA), as herein described.

  提供了一种化合物，其化学式为(I)，能够与β-连环蛋白/TCF-4结合位点相互作用，其结构基本上等同于药效团(IA)，如本文所述。
• INTERACTION INHIBITORS OF TCF-4 WITH BETA-CATENIN
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1406889A2

  公开（公告）日：2004-04-14
• METHODS FOR DIAGNOSING AND TREATING PELVIC PAIN DISORDERS VIA BETA-CATENIN
  申请人：Reeder Jay E.

  公开号：US20100292170A1

  公开（公告）日：2010-11-18

  Methods for diagnosing a pelvic pain disorder that include analyzing samples for increased levels and/or nuclear accumulation of beta-catenin, which indicates presence of the pelvic pain disorder, particularly interstitial cystitis. Therapeutic treatment of a pelvic pain disorder, particularly interstitial cystitis, includes the administration to a patient of an effective amount of an inhibitor of beta-catenin activity. This can be carried out by direct administration of the therapeutic agent or via gene therapy.
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF VASCULAR MALFORMATION
  申请人：IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

  公开号：US20170027896A1

  公开（公告）日：2017-02-02

  An inhibitor of Wnt/β-catenin signaling for use in the treatment and/or prevention of a pathology having vascular malformation is provided. The inhibitor may be a small molecule, a protein, a peptide or an antisense nucleic acid. The invention also relates to pharmaceutical compositions and to method of treatment.
• US8415108B2
  申请人：——

  公开号：US8415108B2

  公开（公告）日：2013-04-09