N-(tert-Butylcarbamoyl-methyl)-2-oxo-N-phenethyl-propionamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(tert-Butylcarbamoyl-methyl)-2-oxo-N-phenethyl-propionamide
• 英文别名: N-[2-(tert-butylamino)-2-oxoethyl]-2-oxo-N-(2-phenylethyl)propanamide
• 化学式: C₁₇H₂₄N₂O₃
• 分子量: 304.389
• InChiKey: DOOMJLMPWNPDQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-[2-(tert-butylamino)-2-oxoethyl]-2-hydroxy-N-(2-phenylethyl)propanamide 在 重铬酸吡啶 、 Celite 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以58%的产率得到N-(tert-Butylcarbamoyl-methyl)-2-oxo-N-phenethyl-propionamide
  参考文献：
  名称：

  A two-step, one-pot synthesis of diverse N-pyruvoyl amino acid derivatives using the Ugi reaction

  摘要：

  A 100-member combinatorial library of alpha -ketoamides, which was designed to search potent cysteine protease inhibitors, was generated by a parallel solution-phase synthesis. A two-step one-pot synthesis, in which the Ugi reaction followed by pyridinium dichromate (PDC) oxidation was employed in the same reaction vessel, easily afforded the alpha -ketoamides in a short time. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00577-1

文献信息

• A two-step, one-pot synthesis of diverse N-pyruvoyl amino acid derivatives using the Ugi reaction
  作者：Masayuki Nakamura、Jun Inoue、Takashi Yamada

  DOI：10.1016/s0960-894x(00)00577-1

  日期：2000.12

  A 100-member combinatorial library of alpha -ketoamides, which was designed to search potent cysteine protease inhibitors, was generated by a parallel solution-phase synthesis. A two-step one-pot synthesis, in which the Ugi reaction followed by pyridinium dichromate (PDC) oxidation was employed in the same reaction vessel, easily afforded the alpha -ketoamides in a short time. (C) 2000 Elsevier Science Ltd. All rights reserved.