3-(1-Acetyl-5-bromoindol-3-yl)pyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(1-Acetyl-5-bromoindol-3-yl)pyrrole-2,5-dione
• 化学式: C₁₄H₉BrN₂O₃
• 分子量: 333.14
• InChiKey: BPALPPXTHHAOQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  68.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Neuroprotective and anti-proliferative compounds
  申请人：——

  公开号：US20040220202A1

  公开（公告）日：2004-11-04

  This invention features ring-substituted pyrrolo-&bgr;-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas I-III, which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation. 1

  本发明涉及公式I-III的环取代吡咯-β-咔啉衍生物和3-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮的环取代和结构衍生物，这些衍生物可用作神经保护和抗增殖化合物。还揭示了这些化合物的制备方法、选择性生物学特征和这些化合物在治疗人类神经系统的各种神经退行性和炎症性疾病以及在治疗各种其他增殖性疾病中的用途，其特征为失去生长或细胞分化控制，包括但不限于癌症和炎症。
• NEUROPROTECTIVE AND ANTI-PROLIFERATIVE COMPOUNDS
  申请人：Aegera Therapeutics Inc.

  公开号：EP1283836A2

  公开（公告）日：2003-02-19
• US7129250B2
  申请人：——

  公开号：US7129250B2

  公开（公告）日：2006-10-31
• [EN] NEUROPROTECTIVE AND ANTI-PROLIFERATIVE COMPOUNDS<br/>[FR] COMPOSÉS NEUROPROTECTEURS ET ANTI-PROLIFÉRATIFS
  申请人：AEGERA THERAPEUTICS INC

  公开号：WO2001087887A2

  公开（公告）日：2001-11-22

  This invention features ring-substituted pyrrolo-β-carboline derivatives and ring-substitution and structural derivatives of 3-(1H-indol-3-yl)-1H-pyrrole-2,5-dione of formulas (I - III), which are useful as neuroprotective and anti-proliferative compounds. Also disclosed are methods for the preparation of these compounds, selected biological profiles and uses of these compounds in the treatment of various neurodegenerative and inflammatory diseases of the human nervous system and in the treatment of various other proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation.