2-[(2S)-4-methyl-7-[methyl(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)carbamoyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 2-[(2S)-4-methyl-7-[methyl(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)carbamoyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
• 化学式: C₂₃H₂₇N₅O₄
• 分子量: 437.5
• InChiKey: WSIKXQUNGPDYEM-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• BENZAZEPINE DERIVATIVES AS ALPHA-V INTEGRIN RECEPTOR ANTAGONISTS
  申请人：Merck & Co., Inc.

  公开号：EP1150965A1

  公开（公告）日：2001-11-07
• EP1150965A4
  申请人：——

  公开号：EP1150965A4

  公开（公告）日：2002-05-15
• US6232308B1
  申请人：——

  公开号：US6232308B1

  公开（公告）日：2001-05-15
• [EN] BENZAZEPINE DERIVATIVES AS ALPHA-V INTEGRIN RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE LA BENZAZEPINE UTILISES COMME ANTAGONISTES DU RECEPTEUR ALPHA-V DE L'INTEGRINE
  申请人：MERCK & CO INC

  公开号：WO2000046215A1

  公开（公告）日：2000-08-10

  The present invention relates to benzazepine derivatives and their use as alpha-V integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphaVbeta3, alphaVbeta5, and/or alphaVbeta6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.