1-[(3S)-3-[2-[4-(6-chloro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-2,3-dihydroindol-1-yl]ethanone;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[(3S)-3-[2-[4-(6-chloro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-2,3-dihydroindol-1-yl]ethanone;hydrochloride
• 化学式: C25H27Cl2N3O
• 分子量: 456.4
• InChiKey: NLGUJPLHIXZROS-FSRHSHDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.87
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  39.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] THE HYDROCHLORIDE OF (S)-(+)-3-[1-[2-(1-ACETYL-2,3-DIHYDRO-1H-INDOL-3-YL)ETHYL]-1,2,3,6-TETRAHYDROPYRIDIN-4-YL]-6-CHLORO-1H-INDOLE<br/>[FR] HYDROCHLORIDE DE (S)-(+)-3-[1[2-(1-ACETYL-2,3-DIHYDRO-1H-INDOL-3-YL)ETHYL]-1,2,3,6-TETRAHYROPYRIDINE-4-YL]-6-CHLORO-1H-INDOLE
  申请人：LUNDBECK & CO AS H

  公开号：WO2003102097A1

  公开（公告）日：2003-12-11

  A hydrochloride of (S)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1H-indole and hydrates and/or solvates thereof, a method for the preparation thereof and the use thereof for the preparation of a pharmaceutical composition.
• [EN] PHARMACEUTICAL COMPOSITION COMPRISING (S)-(+)-3-[1-[2-(1-ACETYL-2,3-DIHYDRO-1H-INDOL-3-YL)ETHYL]-1,2,3,6-TETRAHYDROPYRIDIN-4-YL]-6-CHLORO-1H-INDOLE<br/>[FR] COMPOSITION PHARMACEUTIQUE COMPRENANT DU (S)-(+)-3-[1-[2-(1-ACETYL-2,3-DIHYDRO-1H-INDOL-3-YL)ETHYL]-1,2,3,6-TETRAHYDROPYRIDIN-4-YL]-6-CHLORO-1H-INDOLE
  申请人：LUNDBECK & CO AS H

  公开号：WO2004004717A1

  公开（公告）日：2004-01-15

  A pharmaceutical composition comprising a melt granulate, comprising (S)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1H-indole or a pharmaceutically acceptable salt thereof. The active compound has an effect at dopamine D4 receptors and is useful in the treatment of e.g. schizophrenia, anxiety disorder, depression, aggression and senile dementia.