12-(4-methylpiperazin-1-yl)-8-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.1 maleate | 221058-54-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 12-(4-methylpiperazin-1-yl)-8-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.1 maleate
• 英文别名: (Z)-but-2-enedioic acid;8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothiolo[2,3-b][1,5]benzodiazepine
• CAS: 221058-54-4
• 化学式: C₄H₄O₄*C₂₀H₁₉FN₄S
• 分子量: 482.535
• InChiKey: JODDYHQGERBRCQ-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.13
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Condensed thiophene compounds and pharmaceutical use thereof
  申请人：——

  公开号：US20020042411A1

  公开（公告）日：2002-04-11

  A condensed thiophene compound of the formula (I) 1 wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a novel antipsychotic agent which is effective for both positive symptoms and negative symptoms of schizophrenia, which is associated with less side effects such as extrapyramidal motor disorder and the like and which is less associated with serious side effects such as agranulocytosis and the like. In addition, this compound is also useful as a therapeutic agent of Alzheimer's disease and manic-depressive illness.

  本发明涉及一种式(I)的缩合噻吩化合物，其中每个符号如规范中所定义，其药学上可接受的盐和水合物。本发明的式(I)化合物可用作一种新型抗精神病药物，对于精神分裂症的阳性症状和阴性症状都有效，且副作用较少，如运动障碍等，并且与严重副作用如粒细胞缺乏症等较少相关。此外，该化合物还可用作阿尔茨海默病和躁郁症的治疗剂。
• US6271225B1
  申请人：——

  公开号：US6271225B1

  公开（公告）日：2001-08-07
• US6455521B1
  申请人：——

  公开号：US6455521B1

  公开（公告）日：2002-09-24