2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid;(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid;(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
• 化学式: C33H30ClNO7
• 分子量: 588.0
• InChiKey: NZNKTSHELWPIGD-NPULLEENSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.96
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Implantable or Insertable Medical Devices
  申请人：Boston Scientific Neuromodulation Corporation

  公开号：EP2708247A1

  公开（公告）日：2014-03-19

  The present invention is directed to medical devices comprising a silicone-containing region, a polymeric layer comprising a block copolymer disposed over the silicone-containing region, and a tie layer between the silicone-containing region and the polymeric layer.

  本发明涉及医疗器械，包括含硅区域、设置在含硅区域上的由嵌段共聚物组成的聚合物层以及含硅区域和聚合物层之间的连接层。
• Ureteral stent with drug-releasing structure
  申请人：Boston Scientific Scimed, Inc.

  公开号：US10251741B2

  公开（公告）日：2019-04-09

  According to one aspect of the present disclosure, ureteral stents are provided that comprise an elongated stent body, at least one deployable retention structure, and at least one sleeve and/or sheet of drug-releasing material. In various embodiments, at least one sleeve and/or sheet of drug-releasing material is deployed concurrently with the deployment of at least one deployable retention structure. The ureteral stents of the present disclosure are adapted to release the urologically beneficial drug into a subject.

  根据本公开的一个方面，输尿管支架包括一个细长的支架体、至少一个可展开的固定结构和至少一个药物释放材料套筒和/或薄片。在不同的实施例中，至少一个药物释放材料套筒和/或薄片与至少一个可展开的固定结构同时展开。本公开的输尿管支架适于向受试者释放对泌尿系统有益的药物。
• PRODRUG DERIVATIVES OF CARBOXYLIC ACID DRUGS
  申请人：Bundgaard, Hans

  公开号：EP0278977A1

  公开（公告）日：1988-08-24
• UROLOGICAL MEDICAL DEVICES FOR RELEASE OF THERAPEUTIC AGENTS
  申请人：Boston Scientific Scimed, Inc.

  公开号：EP2136854A2

  公开（公告）日：2009-12-30
• UROLOGICAL MEDICAL DEVICES FOR RELEASE OF PROSTATICALLY BENEFICIAL THERAPEUTIC AGENTS
  申请人：Boston Scientific Scimed, Inc.

  公开号：EP2136855A2

  公开（公告）日：2009-12-30