5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one;diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one;diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
• 化学式: C25H30ClN5O3S4
• 分子量: 612.3
• InChiKey: MTITVLSZZXTPSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.66
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  209
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] COMBINATIONS OF MEDICAMENTS COMPRISING AN ALCOHOL DETERRENT FOR TREATING ALCOHOL DEPENDENCE OR ALCOHOL ABUSE<br/>[FR] COMBINAISONS DE MEDICAMENTS COMPRENANT UN AGENT DE DISSUASION CONTRE L'ALCOOL DESTINEES A TRAITER LA DEPENDANCE A L'ALCOOL OU L'ABUS D'ALCOOL
  申请人：PUREPHARM INC

  公开号：WO2004054570A1

  公开（公告）日：2004-07-01

  Alcohol disorders have been treated with a variety of therapies, including pharmaceutical. Benzodiazepines, are one type of pharmaceutical that has aided in treating the anxiety associated with alcohol disorders, however there are serious risks of abuse and dependence. Disulfiram is another pharmaceutical that provides a deterrent against consuming alcohol since it causes a person to become very ill when combined with alcohol. The deterrent effect of disulfiram is only effective when taken and non-compliance is a major limitation. This invention relates to a combination pharmaceutical medicine of disulfiram and a benzodiazepine that acts in an agonist-aversive manner for people with alcohol disorders. The combination of disulfiram and a benzodiazepine acts to reduce anxiety and deter alcohol consumption at the same time. This invention also relates to other combinations of agonist and aversive medicines to reduce anxiety and deter alcohol consumption. This invention also relates to aversive medicines combined with other agents to treat medical conditions, which medical conditions or agents' effectiveness are negatively impacted by the consumption of ethanol.