4-[2-(dimethylcarbamoyl)-1H-indol-5-yl]-4-hydroxybutanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-[2-(dimethylcarbamoyl)-1H-indol-5-yl]-4-hydroxybutanoic acid
• 化学式: C₁₅H₁₈N₂O₄
• 分子量: 290.31
• InChiKey: JKBGKVNBYJHVCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Derivatives of 4-hydroxybutanoic acid and of its higher homologue as ligands of $g(g)-hydroxybutyrate (ghb) receptors, pharmaceutical compositions containing same and pharmaceutical uses
  申请人：Bourguignon Jean-Jacques

  公开号：US20050113366A1

  公开（公告）日：2005-05-26

  The invention concerns the field of synthesis organic chemistry applied to the pharmaceutical field and concerns novel derivatives of 4-hydroxybutanoic acid and its higher homologue, 5-hydroxypentanoic acid, their crotonic homologues, pharmaceutical compositions containing them and their pharmaceutical uses. Said novel derivatives are capable of binding with γ-hydroxybutyrate (GHB)-specific receptors and hence capable of exhibiting agonist or antagonist properties, in particular for treating sleep disorders, anxiety and general diseases of the central nervous system. The invention also concerns compounds of general formula (I) wherein the substituents are as defined in the description.

  该发明涉及合成有机化学领域应用于制药领域，涉及4-羟基丁酸及其较高同系物5-羟基戊酸的新颖衍生物，它们的丁烯酸同系物，含有它们的药物组合物以及它们的药用。所述新颖衍生物能够与γ-羟基丁酸盐（GHB）特异性受体结合，因此能够表现出激动剂或拮抗剂特性，特别用于治疗睡眠障碍、焦虑和中枢神经系统的一般疾病。该发明还涉及一般式（I）的化合物，其中取代基如描述中所定义。
• DERIVES DE L'ACIDE 4-HYDROXYBUTANOIQUE ET DE SON HOMOLOGUE SUPERIEUR COMME LIGANDS DES RECEPTEURS DU GAMMA-HYDROXYBUTYRATE (GHB) COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET UTILISATIONS PHARMACEUTIQUES
  申请人：Université Louis Pasteur (Etablissement Public à Caractère Scientifique, Culturel et Professionnel)

  公开号：EP1347950B1

  公开（公告）日：2010-02-17