7-[5-(4'-Chloro-biphenyl-4-yl)-oxazol-2-yl]-heptanoic acid hydroxyamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-[5-(4'-Chloro-biphenyl-4-yl)-oxazol-2-yl]-heptanoic acid hydroxyamide
• 英文别名: 7-[5-[4-(4-chlorophenyl)phenyl]-1,3-oxazol-2-yl]-N-hydroxyheptanamide
• 化学式: C₂₂H₂₃ClN₂O₃
• 分子量: 398.889
• InChiKey: GKBWWQHTKOYJBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  辛二酸单甲酯 在 N-甲基吗啉 、 sodium hydroxide 、 羟胺 、 phosphorus pentoxide 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 生成 7-[5-(4'-Chloro-biphenyl-4-yl)-oxazol-2-yl]-heptanoic acid hydroxyamide
  参考文献：
  名称：

  A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units

  摘要：

  A series of structurally novel HDAC inhibitors, in which a hetero aromatic ring connects the spacer with the hydrophobic group, has been designed and synthesized. These new inhibitors are very potent in in vitro enzymatic assays and display antiproliferation activity against two human cancer cell lines. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.07.012

文献信息

• A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units
  作者：Yujia Dai、Yan Guo、Michael L. Curtin、Junling Li、Lori J. Pease、Jun Guo、Patrick A. Marcotte、Keith B. Glaser、Steven K. Davidsen、Michael R. Michaelides

  DOI：10.1016/j.bmcl.2003.07.012

  日期：2003.11

  A series of structurally novel HDAC inhibitors, in which a hetero aromatic ring connects the spacer with the hydrophobic group, has been designed and synthesized. These new inhibitors are very potent in in vitro enzymatic assays and display antiproliferation activity against two human cancer cell lines. (C) 2003 Elsevier Ltd. All rights reserved.