2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid;4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid;4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
• 化学式: C42H46Cl2N4O5
• 分子量: 757.7
• InChiKey: IVOULPMNDYTTCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  53
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Methods and compositions for the selective regulation of chorionic prostanoids
  申请人：Board of Regents, The University of Texas System

  公开号：US20010053765A1

  公开（公告）日：2001-12-20

  Methods for inhibiting the production of specific vasoconstrictive prostanoids, such as thromboxane and prostaglandin F 2&agr; , through the addition of insulin like growth factor, particularly IGF-I or IGF-II, to human placental cells are disclosed. IGF-I is demonstrated to avoid affecting material and placental production of prostaglandin E, human chorionic gonadotropin, PGFM, and 6 -keto-PGF1-alpha by placental cells. Improved methods for vasoregulation of vasoconstrictive diseases of pregnancy are also disclosed. Methods for treating hypertension with IGF-I are also described. Improved methods for inhibiting pre-term labor are also provided. Methods for inducing labor with agents that specifically inhibit insulin like growth factor are also disclosed. Such inhibitors of IGF-I include antibodies, antagonists of IGF-I, and metabolizing enzymes of IGF-I.

  抑制特定血管收缩性前列腺素（如血栓素和前列腺素 F）产生的方法 2&agr； 本研究公开了通过向人类胎盘细胞中添加胰岛素样生长因子，特别是 IGF-I 或 IGF-II，来抑制特定血管收缩性前列腺素（如血栓素和前列腺素 F 2&agr.）的产生的方法。经证实，IGF-I 可避免影响胎盘细胞产生前列腺素 E、人绒毛膜促性腺激素、PGFM 和 6-酮-PGF1-α 的物质和胎盘。此外，还公开了对妊娠期血管收缩性疾病进行血管调节的改进方法。还描述了用 IGF-I 治疗高血压的方法。还提供了抑制早产的改进方法。还公开了使用专门抑制胰岛素样生长因子的药物进行引产的方法。这类 IGF-I 抑制剂包括抗体、IGF-I 的拮抗剂和 IGF-I 的代谢酶。
• US6271201B1
  申请人：——

  公开号：US6271201B1

  公开（公告）日：2001-08-07
• US6461613B2
  申请人：——

  公开号：US6461613B2

  公开（公告）日：2002-10-08