6-hydroxy-2-(2-propoxyphenyl)pyrimidine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-hydroxy-2-(2-propoxyphenyl)pyrimidine-4-carboxamide
• 英文别名: 6-Hydroxy-2-(2-propoxyphenyl)pyrimidine-4-carboxamide；6-oxo-2-(2-propoxyphenyl)-1H-pyrimidine-4-carboxamide
• 化学式: C₁₄H₁₅N₃O₃
• 分子量: 273.291
• InChiKey: GPCIGOMWSAEZKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  93.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-hydroxy-2-(2-propoxyphenyl)pyrimidine-4-carboxamide 以 氯仿 、 水 、 溶剂黄146 、 三氯氧磷 为溶剂， 生成 4-cyano-6-hydroxy-2-(2-propoxyphenyl)pyrimidine
  参考文献：
  名称：

  Method of treating a patient having precancerous lesions with phenyl

  摘要：

  苯基嘧啶酮衍生物对于治疗患有癌前病变的患者非常有用。这些化合物还可用于抑制肿瘤细胞的生长。

  公开号：

  US05874440A1
• 作为产物：
  描述：

  ethyl 6-hydroxy-2-(2-propoxyphenyl)-pyrimidine-4-carboxylate 以 ammonium hydroxide 为溶剂， 生成 6-hydroxy-2-(2-propoxyphenyl)pyrimidine-4-carboxamide
  参考文献：
  名称：

  Method of treating a patient having precancerous lesions with phenyl

  摘要：

  苯基嘧啶酮衍生物对于治疗患有癌前病变的患者非常有用。这些化合物还可用于抑制肿瘤细胞的生长。

  公开号：

  US05874440A1

文献信息

• BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA
  申请人：Combrink Keith D.

  公开号：US20120046285A1

  公开（公告）日：2012-02-23

  The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.

  这项发明提供了用于治疗和/或预防与眼内压增高相关的眼部疾病的组合物和方法。具体来说，这些化合物是激肽酶激动剂。
• Phenylpyrimidones
  申请人：Smith Kline & French Laboratories Limited

  公开号：US05118686A1

  公开（公告）日：1992-06-02

  This invention relates to phenylpyrimidone derivatives which have bronchodilator activity. A compound of the invention is 4-cyano-6-hydroxy-2-(2-propoxyphenyl)pyrimidine.

  本发明涉及具有支气管扩张剂活性的苯基嘧啶衍生物。该发明的一种化合物是4-氰基-6-羟基-2-(2-丙氧基苯基)嘧啶。
• Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives
  申请人：Cell Pathways, Inc.

  公开号：US06239136B1

  公开（公告）日：2001-05-29

  Derivatives of Phenyl Pyrimidinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.

  苯基嘧啶酮的衍生物对于治疗患有癌前病变的患者非常有用。这些化合物也有助于抑制肿瘤细胞的生长。
• Penylpyrimidone derivates and their use as therapeutic agents
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0395328A2

  公开（公告）日：1990-10-31

  Compounds of the formula (1) : and pharmaceutically acceptable salts thereof are described wherein R¹ is C₁₋₆alkyl, C₂₋₆alkenyl, C₃₋₅cycloalkylC₁₋₆alkyl, phenylC₁₋₆alkyl or C₁₋₆alkyl substituted by 1 to 6 fluoro groups; and R² is C₁₋₆alkyl, phenyl, hydroxy, C₁₋₆alkoxy, halo, -NHCOR³, -NHCONHR⁴, 5-tetrazolyl, -CO₂R⁵, cyano, -CONR⁶R⁷, or -NR⁸R⁹ wherein R³ to R⁷ are independently hydrogen or C₁₋₆alkyl and R⁸ and R⁹ are independently hydrogen or C₁₋₆alkyl optionally substituted by hydroxy provided that the carbon atom adjacent to the nitrogen atom is not substituted by hydroxy. Processes for their preparation, pharmaceutical compositions comprising them and their use as medicaments are also described.

  式 (1) ： 及其药学上可接受的盐，其中 R¹ 是 C₁₋₆烷基、C₂₋₆烯基、C₃₋₅烷基、苯基C₁₋₆烷基或被 1 至 6 个氟基团取代的 C₁₋₆ 烷基；而 R² 是 C₁₋₆烷基、苯基、羟基、C₁₋₆烷氧基、卤代、-NHCOR³、-NHCONHR⁴、5-四唑基、-CO₂R⁵、氰基、-CONR⁶R⁷、或-NR⁸R⁹，其中 R³ 至 R⁷ 独立地为氢或 C₁₋₆alkyl，R⁸ 和 R𠞙 独立地为氢或 C₁₋₆alkyl 可选地被羟基取代，条件是与氮原子相邻的碳原子未被羟基取代。 此外，还描述了它们的制备工艺、包含它们的药物组合物以及它们作为药物的用途。
• Methods, compositions, and kits for the treatment of ophthalmic disorders
  申请人：CombinatoRx, Inc.

  公开号：EP2218442A1

  公开（公告）日：2010-08-18

  The invention features methods, compositions and kits comprising a corticosteroid and a non-steroidal immunophilin-dependent immunosuppressant for treating an ophthalmic disorder in a patient, wherein at least one of said corticosteroid and said non-steroidal immunophilin-dependent immunosuppressant is present at a low concentration, in particular wherein said corticosteroid is prednisolone acetate and said non-steroidal immunophilin-dependent immunosuppressant is cyclosporine A.

  本发明的特征是包含皮质类固醇和非类固醇免疫嗜血素依赖性免疫抑制剂的方法、组合物和试剂盒，用于治疗患者的眼科疾病、其中，所述皮质类固醇和所述非类固醇免疫嗜血素依赖性免疫抑制剂中至少有一种以低浓度存在，特别是所述皮质类固醇为醋酸泼尼松龙，所述非类固醇免疫嗜血素依赖性免疫抑制剂为环孢素 A。