(4R,5R)-4-((E)-(R)-3-Methoxycarbonyl-hex-1-enyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4R,5R)-4-((E)-(R)-3-Methoxycarbonyl-hex-1-enyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid methyl ester
• 英文别名: methyl (4R,5R)-4-[(E,3R)-3-methoxycarbonylhex-1-enyl]-2,2,5-trimethyl-1,3-oxazolidine-3-carboxylate
• 化学式: C₁₆H₂₇NO₅
• 分子量: 313.394
• InChiKey: AXPVKVKNGQPUDH-QNEZDRPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  溴丙烷 、 methyl (4S,5R)-4-[(E,1R)-4-methoxy-1-methylsulfonyloxy-4-oxobut-2-enyl]-2,2,5-trimethyl-1,3-oxazolidine-3-carboxylate 生成 (4R,5R)-4-((E)-(R)-3-Methoxycarbonyl-hex-1-enyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Syn-SN2' pathway in the reaction of certain .gamma.-(mesyloxy) .alpha.,.beta.-enoates with RCu(CN)MgX.BF3 reagents. Importance of MgX and bulky R group upon the diastereoselectivity

  摘要：

  The reactions of protected serine- and threonine-derived gamma-(mesyloxy) alpha,beta-unsaturated esters with various magnesio organocyanocopper Lewis acid complexes have been investigated. The formation of syn-S(N)2' products, in addition to the normally expected anti-S(N)2' products, is taken as an indication that the reaction proceeds by a mechanism involving coordination of the magnesiocuprate with the C(delta)-N:C(gamma)-O syn-gamma-(mesyloxy) alpha,beta-enoates.

  DOI：

  10.1021/jo00057a038

文献信息

• Syn-SN2' pathway in the reaction of certain .gamma.-(mesyloxy) .alpha.,.beta.-enoates with RCu(CN)MgX.BF3 reagents. Importance of MgX and bulky R group upon the diastereoselectivity
  作者：Toshiro Ibuka、Tooru Taga、Hiromu Habashita、Kazuo Nakai、Hirokazu Tamamura、Nobutaka Fujii、Yukiyasu Chounan、Hisao Nemoto、Yoshinori Yamamoto

  DOI：10.1021/jo00057a038

  日期：1993.2

  The reactions of protected serine- and threonine-derived gamma-(mesyloxy) alpha,beta-unsaturated esters with various magnesio organocyanocopper Lewis acid complexes have been investigated. The formation of syn-S(N)2' products, in addition to the normally expected anti-S(N)2' products, is taken as an indication that the reaction proceeds by a mechanism involving coordination of the magnesiocuprate with the C(delta)-N:C(gamma)-O syn-gamma-(mesyloxy) alpha,beta-enoates.