7-[2-(3-hydroxy-octyl)-6-oxo-piperidin-1-yl]-heptanoic acid | 697802-52-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: 7-[2-(3-hydroxy-octyl)-6-oxo-piperidin-1-yl]-heptanoic acid
• 英文别名: 7-[2-(3-Hydroxyoctyl)-6-oxopiperidin-1-yl]heptanoic acid
• CAS: 697802-52-1
• 化学式: C₂₀H₃₇NO₄
• 分子量: 355.518
• InChiKey: RHHTZHFLKGVIHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Piperidinyl prostaglandin E analogs
  申请人：ALLERGAN, INC.

  公开号：US20040248854A1

  公开（公告）日：2004-12-09

  The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; 1 wherein X, Y, Z, D and R 3 are as defined in the specification. Also disclosed are compounds comprising 2 or a pharmaceutically acceptable salt or a prodrug thereof; wherein A, X, J, and R 3 are as defined in the specification. Also disclosed are compounds having an &agr; and an &ohgr; chain comprising 3 or derivatives thereof, as defined in the specification or pharmaceutically acceptable salts or prodrugs thereof.

  本发明提供了一种治疗眼压增高或青光眼的方法，包括向患有眼压增高或青光眼的动物施用一定剂量的通式I代表的化合物；其中X、Y、Z、D和R3如规范中定义。还披露了包括2或其药用盐或前药的化合物；其中A、X、J和R3如规范中定义。还披露了具有α和ω链的化合物，包括3或其衍生物，如规范中定义，或其药用盐或前药。
• Treatment of inflammatory bowel disease
  申请人：Old W. David

  公开号：US20050171062A1

  公开（公告）日：2005-08-04

  The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula 1; wherein X, Y, Z, D and R 3 are as defined in the specification. Also useful for the treatment of inflammatory bowel disease are compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein A, X, J, and R 3 are as defined in the specification. Also useful for the treatment of inflammatory bowel disease are compounds having an α and an ω chain comprising or derivatives thereof, as defined in the specification or pharmaceutically acceptable salts or prodrugs thereof.

  本发明提供了一种治疗炎症性肠病的方法，包括向患有眼压增高或青光眼的动物施用一定疗效的一般式1代表的化合物；其中X、Y、Z、D和R3如规范中所定义。还可用于治疗炎症性肠病的化合物包括或其药用盐或前药；其中A、X、J和R3如规范中所定义。还可用于治疗炎症性肠病的化合物包括具有α和ω链或其衍生物，如规范中所定义或其药用盐或前药。
• PIPERIDINYL PROSTAGLANDIN E ANALOGS
  申请人：ALLERGAN, INC.

  公开号：EP1631355A1

  公开（公告）日：2006-03-08
• TREATMENT OF INFLAMMATORY BOWEL DISEASE
  申请人：ALLERGAN, INC.

  公开号：EP1817033A1

  公开（公告）日：2007-08-15
• US6747037B1
  申请人：——

  公开号：US6747037B1

  公开（公告）日：2004-06-08