4-[6-(1H-indol-2-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-[6-(1H-indol-2-yl)pyridazin-3-yl]-1,4-diazabicyclo[3.2.2]nonane
• 化学式: C₁₉H₂₁N₅
• 分子量: 319.4
• InChiKey: UUMMBUCFQAZHOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  48
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] 1,4-DIAZABICYCLO (3,2,2)NONANE DERIVATIVES, PREPARATION AND THERAPEUTICAL USE THEREOF<br/>[FR] DERIVES DE 1,4-DIAZABICYCLO (3,2,2)NONANE, PREPARATION ET UTILISATIONS THERAPEUTIQUES DE CES DERIVES
  申请人：NEUROSEARCH AS

  公开号：WO2004043960A1

  公开（公告）日：2004-05-27

  This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  这项发明涉及新型的二氮杂双环联苯衍生物，发现它们在尼古丁酰胆碱受体上是胆碱能配体，并且可以调节单胺受体和转运体。由于它们的药理特性，该发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或疾病、内分泌疾病或疾病、神经退行性疾病或疾病、炎症、疼痛以及因滥用化学物质而引起的戒断症状相关的疾病或疾病可能有用。
• Novel diazabicyclic biaryl derivatives
  申请人：——

  公开号：US20040127491A1

  公开（公告）日：2004-07-01

  This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及新型的二氮杂双环联苯衍生物，发现它们在尼古丁乙酰胆碱受体上是胆碱能配体，并且调节单胺受体和转运体。由于它们的药理特性，该发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或紊乱、内分泌疾病或紊乱、神经退行性疾病或紊乱、炎症相关的疾病或紊乱、疼痛以及由于滥用化学物质终止而引起的戒断症状可能有用。
• 1,4-DIAZABICYCLO(3,2,2)NONANE DERIVATIVES, PREPARATION AND THERAPEUTICAL USE THEREOF
  申请人：NEUROSEARCH A/S

  公开号：EP1562945B1

  公开（公告）日：2006-11-15
• EP1562945A1
  申请人：——

  公开号：EP1562945A1

  公开（公告）日：2005-08-17
• US7223753B2
  申请人：——

  公开号：US7223753B2

  公开（公告）日：2007-05-29