1-methyl-5-[2-methyl-4-(2-methyl-pyridin-4-ylethynyl)-imidazol-1-yl]-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methyl-5-[2-methyl-4-(2-methyl-pyridin-4-ylethynyl)-imidazol-1-yl]-1H-indole
• 英文别名: 1-Methyl-5-[2-methyl-4-[2-(2-methylpyridin-4-yl)ethynyl]imidazol-1-yl]indole
• 化学式: C₂₁H₁₈N₄
• 分子量: 326.401
• InChiKey: FKIFOPWMXNNPAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES<br/>[FR] DERIVES DE L'IMIDAZOL-4-YL-ETHYNYL-PYRIDINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004080998A1

  公开（公告）日：2004-09-23

  4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated full or in part by metabotropic glutamate receptor 5, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases such as schizophrenia and anxiety, depression, pain and drug dependency.

  4-[1-芳基-咪唑-4-基乙炔基]-2-烷基吡啶和1-杂环芳基-咪唑-4-基乙炔基]-2-烷基吡啶衍生物及其药用可接受盐，用于治疗或预防由代谢型谷氨酸受体5完全或部分介导的疾病，例如神经系统的急性、创伤性和慢性退行性过程，如阿尔茨海默病、老年性痴呆、帕金森病、亨廷顿舞蹈症、肌萎缩侧索硬化和多发性硬化，精神疾病如精神分裂症和焦虑、抑郁、疼痛和药物依赖。
• Imidazole derivatives
  申请人：——

  公开号：US20040229917A1

  公开（公告）日：2004-11-18

  The present invention provides 4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated in full or in part by metabotropic glutamate receptor 5. These disorders include, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases, such as schizophrenia and anxiety, depression, pain and drug dependency.

  本发明提供了4-＆lsqb;1-芳基咪唑-4-乙炔基＆rsqb;-2-烷基吡啶和1-杂环芳基咪唑-4-乙炔基＆rsqb;-2-烷基吡啶衍生物及其药学上可接受的盐，用于治疗或预防完全或部分由代谢型谷氨酸受体5介导的疾病。这些疾病包括，例如，神经系统的急性、创伤性和慢性退化过程，如阿尔茨海默病、老年性痴呆、帕金森病、亨廷顿舞蹈症、肌萎缩侧索硬化症和多发性硬化症，精神疾病，如精神分裂症和焦虑症、抑郁症、疼痛和药物依赖。
• IMIDAZOL-4-YL-ETHYNYL-PYRIDINE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1606277B1

  公开（公告）日：2008-05-14
• EP1606277B8
  申请人：——

  公开号：EP1606277B8

  公开（公告）日：2008-10-15
• US7153874B2
  申请人：——

  公开号：US7153874B2

  公开（公告）日：2006-12-26