(heptan-4-yloxy)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (heptan-4-yloxy)benzene
• 英文别名: Heptan-4-yloxybenzene
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: QYUAPMGUSPMPIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  碘苯 、 4-庚醇 在 copper(l) iodide 、 potassium phosphate tribasic 、 4-吡咯烷基吡啶 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以92%的产率得到(heptan-4-yloxy)benzene
  参考文献：
  名称：

  Ullmann CO coupling of sterically hindered secondary alcohols using excess amount of strongly coordinating monodentate ligands

  摘要：

  A new effective copper catalyzed C-O coupling reaction using excess amount of strongly coordinating monodentate ligands was successfully developed. Among the DMAP-type monodentate ligands, 4-pyrrolidinopyridine afforded the best results. The developed reaction is widely applicable for the synthesis of various hindered or acyclic secondary alkyl-aryl ethers. In this study, a novel and remarkable acceleration of the coupling reaction using excess amount of monodentate ligands was discovered. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.01.095

文献信息

• THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF
  申请人：LION bioscience AG

  公开号：EP1150565A1

  公开（公告）日：2001-11-07
• US4304683A
  申请人：——

  公开号：US4304683A

  公开（公告）日：1981-12-08
• [EN] THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF<br/>[FR] DERIVES DE THIAZOLE ET LEURS BANQUES COMBINATOIRES
  申请人：TREGA BIOSCIENCES INC

  公开号：WO2000045635A1

  公开（公告）日：2000-08-10

  The present invention relates to novel thiazole compounds of formula (I): wherein q, R1, R2, R3, R4, R5, R6, R7 and R8 have the meanings provided below. The invention further relates to combinatorial libraries containing at least two or more such compounds, and to methods of preparing combinatorial libraries composed of such compounds.