(19S)-19-ethyl-7,19-dihydroxy-10-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: (19S)-19-ethyl-7,19-dihydroxy-10-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• 化学式: C₂₁H₁₈N₂O₅
• 分子量: 378.4
• InChiKey: SQLZJAZKTFQADW-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• BIFUNCTIONAL HYDROXY-BISPHOSPHONIC ACID DERIVATIVES
  申请人：Egorov Maxim

  公开号：US20140086843A1

  公开（公告）日：2014-03-27

  The present invention relates to a bifunctional hydroxy-bisphosphonic acid derivative of formula (I) below: or a pharmaceutically-acceptable salt thereof, a method for producing the same, pharmaceutical compositions containing the same, and the use thereof as a medicament, as well as a compound of formula (II) below: or a pharmaceutically-acceptable salt thereof, and the use thereof for producing a vectorized molecule of therapeutic or diagnostic purpose.

  本发明涉及以下式子(I)的双功能羟基双膦酸衍生物或其药学上可接受的盐，以及制备该衍生物的方法，含有该衍生物的药物组合物以及其作为药物的用途，以及以下式子(II)的化合物或其药学上可接受的盐，以及用于生产用于治疗或诊断目的的载体化分子的用途。
• [EN] CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF<br/>[FR] ANALOGUES DE CAMPTOTHECINE ET METHODES DE PREPARATION
  申请人：UNIV PITTSBURGH

  公开号：WO2000035924A1

  公开（公告）日：2000-06-22

  A compound and a method of synthesizing a compound having general formula (1): wherein R?1 and R2¿ are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxy group, an aryloxy group, an acyloxy group, -OC(O)ORd, wherein Rd is an alkyl group, a carbamoyloxy group, a halogen, a hydroxy group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, an acyl group, an amino group, -SRc, wherein Rc is hydrogen, an acyl group, an alkyl group, or an aryl group, or R?1 and R2¿ together form a group of the formula -O(CH¿2?)nO- wherein n represents the integer 1 or 2; R?3¿ is H, F, a halogen atom, a nitro group, an amino group, a hydroxy group, or a cyano group; or R?2 and R3¿ together form a group of the formula -O(CH¿2?)n O- wherein n represents the integer 1 or 2; R?4¿ is H, a trialkylsilyl group, F, a C¿1-3? alkyl group, a C2-3 alkenyl group, a C2-3 alkynyl group, or a C1-3 alkoxy group; R?5¿ is a C¿1-10? alkyl group, an allyl group, a benzyl group or a propargyl group; and R?6, R7 and R8¿ are independently a C¿1-10? alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, an aryl group or a -(CH2)NR?9¿ group, wherein N is an integer within the range of 1 through 10 and R9 is a hydroxy group, alkoxy group, an amino group, alkylamino group, a dialkylamino group, a halogen atom, a cyano group or a nitro group; and R11 is an alkylene group or an alkenylene group, and pharmaceutically acceptable salts thereof.

  一种化合物及其合成方法，其具有通式（1）： 其中R1和R2独立且相同或不同，可以是氢、烷基、烯基、苄基、炔基、烷氧基、芳氧基、酰氧基、-OC（O）ORd（其中Rd为烷基、氨基甲酰氧基、卤素、羟基、硝基、氰基、叠氮基、甲酰基、肼基、酰基、氨基、-SRc（其中Rc为氢、酰基、烷基或芳基），或R1和R2组成式为-O（CH2）nO-的基团，其中n表示整数1或2；R3为氢、氟、卤素原子、硝基、氨基、羟基或氰基；或R2和R3组成式为-O（CH2）nO-的基团，其中n表示整数1或2；R4为氢、三烷基硅基、氟、C1-3烷基、C2-3烯基、C2-3炔基或C1-3烷氧基；R5为C1-10烷基、烯丙基、苄基或丙炔基；R6、R7和R8独立地为C1-10烷基、C2-10烯基、C2-10炔基、芳基或-(CH2)NR9（其中N为1至10的整数，R9为羟基、烷氧基、氨基、烷基氨基、二烷基氨基、卤素原子、氰基或硝基）；R11为烷基或烯基，以及其药物可接受的盐。
• Camptothecin derivatives and process for preparing same
  申请人：KABUSHIKI KAISHA YAKULT HONSHA

  公开号：EP0325247A1

  公开（公告）日：1989-07-26

  New camptothecin derivatives and a process for preparing same are disclosed, which are represented by the general formula: wherein R¹ represents a lower alkyl group, R² represents a hydrogen atom or an amino, hydroxyl, lower acylamino or lower alkoxy group, R³ represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, nitro, amino, cyano or di(lower alkyl)amino group, R⁴ represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, lower alkylthio, amino, cyano or di(lower alkyl)amino group, and R⁵ represents a hydrogen or halogen atom or a hydroxyl or lower alkoxy group, with the proviso that all of the R², R³, R⁴ and R⁵ substituents should not be a hydrogen atom and also that if any one of the R², R³, R⁴ and R⁵ is a hydroxyl or lower alkoxy group, all of the other three substituents should not be a hydrogen atom. The new camptothecin derivatives are useful as anti-tumor drugs or intermediates therefor.

  本发明公开了新喜树碱衍生物及其制备方法，它们由通式表示： 其中 R¹ 代表低级烷基，R² 代表氢原子或氨基、羟基、低级酰氨基或低级烷氧基，R³ 代表氢原子或卤素原子或低级烷基、羟基、低级烷氧基、硝基、氨基、氰基或二（低级烷基）氨基，R⁴ 代表氢原子或卤素原子或低级烷基、羟基、低级烷氧基、低级烷硫基、氨基、氰基或二（低级烷基）氨基，以及 R⁵ 代表氢原子或卤素原子或低级烷基、羟基、低级烷氧基、低级烷硫基、氨基、氰基或二（低级烷基）氨基、R⁴代表氢原子、卤素原子或低级烷基、羟基、低级烷氧基、低级烷硫基、氨基、氰基或二（低级烷基）氨基，R⁵代表氢原子、卤素原子或羟基或低级烷氧基，但所有 R²、R³、R⁴ 和 R⁵ 取代基都不能是氢原子，而且如果 R²、R³、R⁴ 和 R⁵ 中的任何一个是羟基或低级烷氧基，则其他三个取代基都不能是氢原子。新喜树碱衍生物可用作抗肿瘤药物或其中间体。
• PROCESS FOR THE MANUFACTURING OF 7-ETHYL-10-HYDROXY CAMPTOTHECIN
  申请人：Fermion Oy

  公开号：EP1846412B1

  公开（公告）日：2009-10-21
• CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF
  申请人：UNIVERSITY OF PITTSBURGH

  公开号：EP1140948A1

  公开（公告）日：2001-10-10