7-Bromo-5-(o-chlorophenyl)-3-propoxy-1,2-dihydro-3h-1,4-benzodiazepin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-Bromo-5-(o-chlorophenyl)-3-propoxy-1,2-dihydro-3h-1,4-benzodiazepin-2-one
• 英文别名: 7-bromo-5-(2-chlorophenyl)-3-propoxy-1,3-dihydro-1,4-benzodiazepin-2-one
• 化学式: C₁₈H₁₆BrClN₂O₂
• 分子量: 407.7
• InChiKey: LFLUSMKRICMUOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PHARMACEUTICAL COMPOUND, THE METHOD OF ITS MAKING AND USE AS MEDICINAL AGENT
  申请人：Reder, Anatoliy

  公开号：EP3898596A1

  公开（公告）日：2021-10-27
• THE USE OF 7-BROMO-5-(O-CHLOROPHENYL)-3-PROPOXY-1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2-ONE FOR INHIBITION OF NEUROPATHIC PAIN AND SEIZURES OF DIFFERENT ETIOLOGY
  申请人："INTERCHEM" SUBSIDIARY LIABILITY COMPANY

  公开号：US20210169895A1

  公开（公告）日：2021-06-10

  The invention relates to medical chemistry, in particular to the use of 7-bromo-5-(o-chlorophenyl)-3-propoxy-1,2-di-hydro-3H-1,4-benzodiazepin-2-one as a drug which inhibits neuropathic pain without the formation of defects in the gastric mucosa (ulcerogenic effect), and possesses an anticonvulsant property.
• [EN] THE USE OF 7-BROMO-5-(O-CHLOROPHENYL)-3-PROPOXY-1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2-ONE FOR INHIBITION OF NEUROPATHIC PAIN AND SEIZURES OF DIFFERENT ETIOLOGY<br/>[FR] UTILISATION DE 7-BROMO-5-(O-CHLOROPHÉNYL)-3-PROPOXY -1,2-DIHYDRO -3 H -1,4-BENZODIAZÉPIN-2-ONE POUR INHIBER LA DOULEUR NEUROPATHIQUE ET LES CRISES D'ÉTIOLOGIE DIFFÉRENTE
  申请人：INTERCHEM SUBSIDIARY LIABILITY COMPANY

  公开号：WO2018067102A1

  公开（公告）日：2018-04-12

  The invention relates to medical chemistry, in particular to the use of 7-bromo-5-(o-chlorophenyl)-3-propoxy-l,2-dihydro-3H-l,4-benzodiazepin-2-one as a drug which inhibits neuropathic pain without the formation of defects in the gastric mucosa (ulcerogenic effect), and possesses an anticonvulsant property.
• [EN] PHARMACEUTICAL COMPOUND, THE METHOD OF ITS MAKING AND USE AS MEDICINAL AGENT<br/>[FR] COMPOSÉ PHARMACEUTIQUE, SON PROCÉDÉ DE FABRICATION ET SON UTILISATION EN TANT QU'AGENT THÉRAPEUTIQUE
  申请人：REDER ANATOLIY

  公开号：WO2020131000A1

  公开（公告）日：2020-06-25

  The invention relates to a crystalline form of the Compound (I), wherein the crystalline form displays its strongest reflection, stated as a 2Θ value, at 25±0.2°, in an X-ray powder diffraction pattern. The invention also relates to a method of making this crystalline form, as well as pharmaceutical compositions comprising thereof. Furthermore, the invention relates to methods of using this crystalline form as a medicament and in the treatment of pain.