3-(3,5-dichloro-6-hydroxy-2-pyridylthio)propanoic acid

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-(3,5-dichloro-6-hydroxy-2-pyridylthio)propanoic acid
• 英文别名: 3-((3,5-Dichloro-6-hydroxypyridin-2-yl)thio)propanoic acid；3-[(3,5-dichloro-6-oxo-1H-pyridin-2-yl)sulfanyl]propanoic acid
• 化学式: C₈H₇Cl₂NO₃S
• 分子量: 268.12
• InChiKey: OPCIXVNBLBTILX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,5,6-三氯吡啶-2-醇 在 palladium 10% on activated carbon 、 氢气 、 sodium hydride 、 potassium hydroxide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、303.99 kPa 条件下， 反应 42.0h， 生成 3-(3,5-dichloro-6-hydroxy-2-pyridylthio)propanoic acid
  参考文献：
  名称：

  TCP의 면역분석적 검출에 이용되는 합텐의 제조 방법

  摘要：

  这项发明涉及一种用于免疫分析检测TCP（3,5,6-三氯-2-吡啶醇）的合成物之一，即3-(3,5-二氯-6-羟基-2-吡啶基)丙酸的制备方法。利用本发明的制备方法，不仅可以高产率地制备3-(3,5-二氯-6-羟基-2-吡啶基)丙酸，还可以减少制备所需的时间和成本。

  公开号：

  KR20170115814A

文献信息

• Monitoring of the Organophosphate Pesticide Chlorpyrifos in Vegetable Samples from Local Markets in Northern Thailand by Developed Immunoassay
  作者：Surat Hongsibsong、Tippawan Prapamontol、Ting Xu、Bruce D. Hammock、Hong Wang、Zi-Jian Chen、Zhen-Lin Xu

  DOI：10.3390/ijerph17134723

  日期：——

  Chlorpyrifos is an organophosphate pesticide that is wildly used among farmers for crop protection. However, there are concerns regarding its contamination in the environment and food chain. In the present study, an in-house indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) specific for detecting chlorpyrifos is developed and validated against gas chromatography–flame photometric detection (GC-FPD) as the conventional method. The developed ic-ELISA was used for detecting chlorpyrifos residue in vegetable samples. The developed ic-ELISA showed good sensitivity to chlorpyrifos at an IC50 of 0.80 µg/kg, with low cross-reactivity to other organophosphate pesticides. The 160 samples were collected from local markets located in the Chiang Rai, Chiang Mai, and Nan provinces in northern Thailand. The positive rate of chlorpyrifos residues in the vegetable samples was 33.8%, with the highest levels found in cucumbers, coriander, and morning glory, at 275, 145, and 35.3 µg/kg, respectively. The highest median levels of chlorpyrifos found in the detected samples were Chinese cabbage (332 μg/kg), cucumber (146.3 μg/kg) and Chinese Kale (26.95 μg/kg). The developed ic-ELISA is suitable for the rapid quantitation of chlorpyrifos residues.

  氯氰菊酯是一种有机磷杀虫剂，广泛用于农民进行作物保护。然而，人们对其在环境和食物链中的污染存在担忧。在本研究中，开发并验证了一种用于检测氯氰菊酯的室内间接竞争酶联免疫吸附测定法（ic-ELISA），并与气相色谱-火焰光度检测（GC-FPD）作为传统方法进行了比较。开发的ic-ELISA被用于检测蔬菜样品中的氯氰菊酯残留。开发的ic-ELISA对氯氰菊酯表现出良好的灵敏度，IC50为0.80 µg/kg，对其他有机磷杀虫剂的交叉反应性低。从泰国北部的清莱、清迈和南府的当地市场收集了160个样品。蔬菜样品中氯氰菊酯残留的阳性率为33.8%，黄瓜、香菜和空心菜中发现的氯氰菊酯水平最高，分别为275、145和35.3 µg/kg。在检测到的样品中，氯氰菊酯的最高中位数水平分别为大白菜（332 μg/kg）、黄瓜（146.3 μg/kg）和芥兰（26.95 μg/kg）。开发的ic-ELISA适用于快速定量氯氰菊酯残留。
• Development of an Enzyme-Linked Immunosorbent Assay for 3,5,6-Trichloro-2-pyridinol. 1. Production and Characterization of Monoclonal Antibodies
  作者：Juan J. Manclús、Angel Montoya

  DOI：10.1021/jf950656p

  日期：1996.1.1

  3,5,6-Trichloro-2-pyridinol (TCP) is the major degradation product of both the widely used chlorpyrifos and chlorpyrifos-methyl insecticides and the herbicide triclopyr. In this paper we describe the development of immunoassays for the detection of this metabolite. With this aim, two types of haptens were synthesized, with spacer attachment either through the 6-position of the pyridyl ring or through the hydroxyl group. Protein conjugates of these haptens were used for the immunization of mice to produce monoclonal antibodies (MAbs). From haptens of the former type, a panel of MAbs displaying 50% inhibition (I-50) for TCP in the range 1-10 nM was obtained. Characterization of these MAbs showed their high affinity and specificity for TCP. The best MAbs were used in various assay formats in combination with homologous and heterologous assay haptens. Several immunoassays with I-50 lower than 1 nM were developed. These immunoassays are potentially very valuable analytical tools for the determination of TCP in food and in the environment, as well as for monitoring human exposure to chlorpyrifos.
• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.
• METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20210317407A1

  公开（公告）日：2021-10-14

  Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
• [EN] PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS<br/>[FR] AGENTS DE CIBLAGE DE TUMEUR À LYMPHOCYTES T CAR (CTCT) D'ÉTHER DE PHOSPHOLIPIDE (PLE)
  申请人：SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST

  公开号：WO2018148224A1

  公开（公告）日：2018-08-16

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.