N-[2-benzoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide (Z)-2-butenedioate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-benzoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide (Z)-2-butenedioate
• 英文别名: N-[2-Benzoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide (Z)-2-Butenedioate；[1-[(Z)-[amino(pyridin-3-yl)methylidene]amino]oxy-3-piperidin-1-ylpropan-2-yl] benzoate;(Z)-but-2-enedioic acid
• 化学式: C₄H₄O₄*C₂₁H₂₆N₄O₃
• 分子量: 498.536
• InChiKey: TWXZKNBXNXAUBW-BTJKTKAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.14
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  165
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  苯甲酰氯 、 顺丁烯二酸 、 N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-3-pyridine-carboximidamide 在 sodium hydroxide 、 sodium carbonate 作用下， 以 丙酮 、 苯 为溶剂， 生成 N-[2-benzoyloxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide (Z)-2-butenedioate
  参考文献：
  名称：

  Pharmaceutical products for curing and preventing illnesses connected

  摘要：

  本发明涉及一种治疗或预防由受损内皮细胞引起的疾病的方法，其中该方法包括向患者施用包含以下通式（I）的羟胺衍生物的产品： ##STR1## 但要注意，在通式（I）的化合物中，当X包括一个--NR^3R^4基团，而Y包括一个羟基时，X基团与Y取代基会缩合形成由通式（III）表示的分子内环： ##STR2##

  公开号：

  US06143741A1

文献信息

• Pharmaceutical products for curing and preventing illnesses connected
  申请人：BIOREX Kutato es Fejleszo Rt.

  公开号：US06143741A1

  公开（公告）日：2000-11-07

  The invention relates to a method of treating or preventing illnesses resulting from damaged endothelial cells, wherein the method comprises administering to a patient a product comprising hydroxylamine derivatives of the general formulae (I) ##STR1## with the proviso that in the compounds of general formula (I) when X comprises a --NR.sup.3 R.sup.4 group and Y comprises a hydroxyl group, the X group is condensed with the Y substituent to form an intramolecular ring represented by general formula (Ill) ##STR2##

  本发明涉及一种治疗或预防由受损内皮细胞引起的疾病的方法，其中该方法包括向患者施用包含以下通式（I）的羟胺衍生物的产品： ##STR1## 但要注意，在通式（I）的化合物中，当X包括一个--NR^3R^4基团，而Y包括一个羟基时，X基团与Y取代基会缩合形成由通式（III）表示的分子内环： ##STR2##
• Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof
  申请人：CytRx Corporation

  公开号：US07148239B2

  公开（公告）日：2006-12-12

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  本发明提供了一种提高细胞中分子伴侣表达或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加压力。或者，在细胞受到诱导细胞分子伴侣表达的生理应激之前，可以向细胞中施加羟胺衍生物。最好，接受羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式（I）或（II）。本发明还提供了落在式（I）和（II）范围内的新型羟胺衍生物，以及包含所述化合物的药物和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof
  申请人：CytRx Corporation

  公开号：US07745465B2

  公开（公告）日：2010-06-29

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理暴露于诱导细胞分子伴侣表达的生理应激下的细胞，以增加压力。另外，可以在细胞暴露于诱导细胞分子伴侣表达的生理应激之前给细胞施加羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新型羟胺衍生物，以及包含所述化合物的药物和/或化妆品组合物。
• PHARMACEUTICAL PRODUCTS FOR CURING AND PREVENTING DISEASES RESULTING FROM THE DAMAGING OF THE VASCULAR ENDOTHELIAL CELLS
  申请人：CYTRX CORPORATION

  公开号：EP0966283B1

  公开（公告）日：2006-06-14
• Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
  申请人：Biorex Research & Development Co.

  公开号：US06653326B1

  公开（公告）日：2003-11-25

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively; an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括将暴露于诱导细胞表达分子伴侣的生理应激的细胞用有效量的某种羟胺衍生物进行处理，以增加应激。或者；可以在细胞暴露于诱导细胞表达分子伴侣的生理应激之前向细胞施加羟胺衍生物。最好，施加羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式（I）或（II）。本发明还提供了新颖的羟胺衍生物，属于式（I）和（II）范围内，以及包含所述化合物的药用和/或化妆品组合物。