hendecylamidine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: hendecylamidine
• 英文别名: Undecanimidamide
• 化学式: C₁₁H₂₄N₂
• 分子量: 184.325
• InChiKey: VVWBLYNUPSHZOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  49.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  hendecylamidine 、 2-bromo-1-(1-tosyl-1H-indol-3-yl)ethanone 在 potassium hydrogencarbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 以43%的产率得到
  参考文献：
  名称：

  Marine-Natural-Product Development: First Discovery of Nortopsentin Alkaloids as Novel Antiviral, Anti-phytopathogenic-Fungus, and Insecticidal Agents

  摘要：

  Nortopsentin alkaloids were found to have potent antiviral, anti-phytopathogenic-fungus, and insecticidal activities for the first time. Antiviral-activity tests revealed that these compounds were very sensitive to substituents, so a series of nortopsentin derivatives were designed, synthesized, and systematically evaluated for their antiviral activities against TMV, their fungicidal activities, and their insecticidal activities on the basis of a structural-diversity-derivation strategy. Compounds 2e (in vivo inactivation-, curative-, and protective-activity inhibitory rates of 50, 59, and 56%, respectively, at 500 mu g/mL) and 2k (in vivo inactivation-, curative-, and protective-activity inhibitory rates of 60, 58, and 52%, respectively, at 500 mu g/mL), with excellent antiviral activities and good physicochemical properties, emerged as new lead compounds for novel-antiviral-agent development. Further fungicidal-activity tests revealed that these alkaloids displayed broad-spectrum fungicidal activities. Compounds 2f, 2h, and 2j emerged as new lead compounds for antifungal-activity research. Additionally, all the compounds displayed good insecticidal activities against five kinds of insects, including Mythimna separate, Helicoverpa armigera, Ostrinia nubilalis, Plutella xylostella, and Culex pipiens pallens.

  DOI：

  10.1021/acs.jafc.8b00507
• 作为产物：
  描述：

  N-十一烷基腈 在 盐酸羟胺 、 氢气 、 碳酸氢钠 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 17.0h， 生成 hendecylamidine
  参考文献：
  名称：

  Marine-Natural-Product Development: First Discovery of Nortopsentin Alkaloids as Novel Antiviral, Anti-phytopathogenic-Fungus, and Insecticidal Agents

  摘要：

  Nortopsentin alkaloids were found to have potent antiviral, anti-phytopathogenic-fungus, and insecticidal activities for the first time. Antiviral-activity tests revealed that these compounds were very sensitive to substituents, so a series of nortopsentin derivatives were designed, synthesized, and systematically evaluated for their antiviral activities against TMV, their fungicidal activities, and their insecticidal activities on the basis of a structural-diversity-derivation strategy. Compounds 2e (in vivo inactivation-, curative-, and protective-activity inhibitory rates of 50, 59, and 56%, respectively, at 500 mu g/mL) and 2k (in vivo inactivation-, curative-, and protective-activity inhibitory rates of 60, 58, and 52%, respectively, at 500 mu g/mL), with excellent antiviral activities and good physicochemical properties, emerged as new lead compounds for novel-antiviral-agent development. Further fungicidal-activity tests revealed that these alkaloids displayed broad-spectrum fungicidal activities. Compounds 2f, 2h, and 2j emerged as new lead compounds for antifungal-activity research. Additionally, all the compounds displayed good insecticidal activities against five kinds of insects, including Mythimna separate, Helicoverpa armigera, Ostrinia nubilalis, Plutella xylostella, and Culex pipiens pallens.

  DOI：

  10.1021/acs.jafc.8b00507

文献信息

• [EN] CONDENSED PYRAMIDINE COMPOUNDS AS INHIBITORS OF VOLTAGE-GATED ION CHANNELS<br/>[FR] COMPOSES DE PYRAMIDINE CONDENSES UTILISES COMME INHIBITEURS DE CANAUX IONIQUES POTENTIEL-DEPENDANTS
  申请人：VERTEX PHARMA

  公开号：WO2005014558A1

  公开（公告）日：2005-02-17

  The present invention relates to compounds of formula (I) useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. Wherein R1, R2, X1-X4, P, and ring A are as defined in the present application.

  本发明涉及一种公式（I）的化合物，其可用作电压门控钠通道的抑制剂。本发明还提供了包含该发明化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病的方法。其中，R1、R2、X1-X4、P和环A的定义如本申请所述。
• Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
  申请人：Codexis, Inc.

  公开号：US10196667B2

  公开（公告）日：2019-02-05

  The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase.

  本公开涉及将氨基酸脱氢酶与由酮还原酶组成的辅助因子再生系统结合使用。在具体的实施方案中，该工艺可用于使用亮氨酸脱氢酶制备 L-叔亮氨酸。
• 1, 3-THIAZOL-2 (3H) -YLIDENE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
  申请人：ABBOTT LABORATORIES

  公开号：EP2142522A1

  公开（公告）日：2010-01-13
• PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM
  申请人：Codexis, Inc.

  公开号：US20170292141A1

  公开（公告）日：2017-10-12

  The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase.
• [EN] 1, 3-THIAZOL-2 (3H) -YLIDENE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS<br/>[FR] NOUVEAUX COMPOSÉS EN TANT QUE LIGANDS DE RÉCEPTEURS CANNABINOÏDES
  申请人：ABBOTT LAB

  公开号：WO2008121558A1

  公开（公告）日：2008-10-09

  [EN] The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
  [FR] L'invention concerne des composés contenant du thiazolylidène de la formule (I), dans laquelle R1, R2, R3, R4, L2 et A sont tels que définis dans la description. Des compositions comprenant de tels composés, et des procédés pour traiter des états et troubles en utilisant de tels composés et de telles compositions sont également décrits.