4-aminomethylheptane-4-sulfonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 4-aminomethylheptane-4-sulfonic acid
• 英文别名: 4-(Aminomethyl)heptane-4-sulfonic acid；4-(aminomethyl)heptane-4-sulfonic acid
• 化学式: C₈H₁₉NO₃S
• 分子量: 209.31
• InChiKey: FAGPQAHDSLCQSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-庚酮 在 甲酸 、 氨 、 双氧水 、 potassium thioacyanate 、 sodium hydride 、 silver nitrate 作用下， 以 甲醇 为溶剂， 反应 47.0h， 生成 4-aminomethylheptane-4-sulfonic acid
  参考文献：
  名称：

  Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen

  摘要：

  We have analyzed the level of gene coregulation, using gene expression patterns measured across the National Cancer Institute's 60 tumor cell panels (NCI60), in the context of predefined pathways or functional categories annotated by KEGG (Kyoto Encyclopedia of Genes and Genomes), BioCarta, and GO (Gene Ontology). Statistical methods were used to evaluate the level of gene expression coherence (coordinated expression) by comparing intra- and interpathway gene-gene correlations. Our results show that gene expression in pathways, or groups of functionally related genes, has a significantly higher level of coherence than that of a randomly selected set of genes. Transcriptional-level gene regulation appears to be on a "need to be" basis, such that pathways comprising genes encoding closely interacting proteins and pathways responsible for vital cellular processes or processes that are related to growth or proliferation, specifically in cancer cells, such as those engaged in genetic information processing, cell cycle, energy metabolism, and nucleotide metabolism, tend to be more modular (lower degree of gene sharing) and to have genes significantly more coherently expressed than most signaling and regular metabolic pathways. Hierarchical clustering of pathways based on their differential gene expression in the NCI60 further revealed interesting interpathway communications or interactions indicative of a higher level of pathway regulation. The knowledge of the nature of gene expression regulation and biological pathways can be applied to understanding the mechanism by which small drug molecules interfere with biological systems. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.ygeno.2005.11.011

文献信息

• [EN] CLEANSER COMPOSITION<br/>[FR] COMPOSITION NETTOYANTE<br/>[JA] 洗浄剤組成物
  申请人：SHISEIDO CO LTD

  公开号：WO2019203040A1

  公开（公告）日：2019-10-24

  洗浄剤組成物は、（Ａ）炭素数８～２４の脂肪酸又はその塩と、（Ｂ）タウリン誘導体又はその塩と、（Ｃ）グリセリン誘導体と、を含有する。成分（Ａ）と成分（Ｂ）のモル比は、成分（Ａ）１モルに対して成分（Ｂ）が０．５モル～２モルである。
• Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen
  作者：Ruili Huang、Anders Wallqvist、David G. Covell

  DOI：10.1016/j.ygeno.2005.11.011

  日期：2006.3

  We have analyzed the level of gene coregulation, using gene expression patterns measured across the National Cancer Institute's 60 tumor cell panels (NCI60), in the context of predefined pathways or functional categories annotated by KEGG (Kyoto Encyclopedia of Genes and Genomes), BioCarta, and GO (Gene Ontology). Statistical methods were used to evaluate the level of gene expression coherence (coordinated expression) by comparing intra- and interpathway gene-gene correlations. Our results show that gene expression in pathways, or groups of functionally related genes, has a significantly higher level of coherence than that of a randomly selected set of genes. Transcriptional-level gene regulation appears to be on a "need to be" basis, such that pathways comprising genes encoding closely interacting proteins and pathways responsible for vital cellular processes or processes that are related to growth or proliferation, specifically in cancer cells, such as those engaged in genetic information processing, cell cycle, energy metabolism, and nucleotide metabolism, tend to be more modular (lower degree of gene sharing) and to have genes significantly more coherently expressed than most signaling and regular metabolic pathways. Hierarchical clustering of pathways based on their differential gene expression in the NCI60 further revealed interesting interpathway communications or interactions indicative of a higher level of pathway regulation. The knowledge of the nature of gene expression regulation and biological pathways can be applied to understanding the mechanism by which small drug molecules interfere with biological systems. (c) 2005 Elsevier Inc. All rights reserved.