1-(cyclohexylcarbamoyloxy)-1-(2-nitrophenyl)-2,4-hexadiene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(cyclohexylcarbamoyloxy)-1-(2-nitrophenyl)-2,4-hexadiene
• 英文别名: [(2E,4E)-1-(2-nitrophenyl)hexa-2,4-dienyl] N-cyclohexylcarbamate
• 化学式: C₁₉H₂₄N₂O₄
• 分子量: 344.411
• InChiKey: XQBZBCXKKUKIFN-MHCRVGIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(cyclohexylcarbamoyloxy)-1-(2-nitrophenyl)-2,4-hexadiene 以 甲醇 为溶剂， 反应 1.75h， 以72%的产率得到环己基氨基甲酸
  参考文献：
  名称：

  Pentadienylnitrobenzyl and Pentadienylnitropiperonyl Photochemically Removable Protecting Groups

  摘要：

  New photochemically removable: protecting groups have been developed based on classical nitrobenzyl compounds modified by the inclusion of a pentadienyl group. It serves to trap through an internal Diels-Alder reaction the nitroso group produced as part of the photochemical deprotection process, preventing its further photochemistry or chemical reactions with nucleophiles.

  DOI：

  10.1021/jo982383d
• 作为产物：
  描述：

  环己基异氰酸酯 、 1-(2-nitrophenyl)-2,4-hexadien-1-ol 在 甲基锂 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 0.75h， 以84%的产率得到1-(cyclohexylcarbamoyloxy)-1-(2-nitrophenyl)-2,4-hexadiene
  参考文献：
  名称：

  Pentadienylnitrobenzyl and Pentadienylnitropiperonyl Photochemically Removable Protecting Groups

  摘要：

  New photochemically removable: protecting groups have been developed based on classical nitrobenzyl compounds modified by the inclusion of a pentadienyl group. It serves to trap through an internal Diels-Alder reaction the nitroso group produced as part of the photochemical deprotection process, preventing its further photochemistry or chemical reactions with nucleophiles.

  DOI：

  10.1021/jo982383d

文献信息

• Pentadienylnitrobenzyl and Pentadienylnitropiperonyl Photochemically Removable Protecting Groups
  作者：Michael C. Pirrung、Yong Rok Lee、Kaapjoo Park、James B. Springer

  DOI：10.1021/jo982383d

  日期：1999.7.1

  New photochemically removable: protecting groups have been developed based on classical nitrobenzyl compounds modified by the inclusion of a pentadienyl group. It serves to trap through an internal Diels-Alder reaction the nitroso group produced as part of the photochemical deprotection process, preventing its further photochemistry or chemical reactions with nucleophiles.