trans-6-Methoxy-2-oxo-12-methyl-1.2.3.4.9.10.11.12-octahydro-phenanthren

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: trans-6-Methoxy-2-oxo-12-methyl-1.2.3.4.9.10.11.12-octahydro-phenanthren
• 英文别名: 5alpha-12-METHOXY-4,4-BISNOR-8,11,13-PODOCARPATRIEN-3-ONE；(4aS,10aS)-6-methoxy-4a-methyl-1,3,4,9,10,10a-hexahydrophenanthren-2-one
• 化学式: C₁₆H₂₀O₂
• 分子量: 244.334
• InChiKey: MMDQZMROSQWSDC-LRDDRELGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MOLECULAR INHIBITORS OF THE WNT/BETA-CATENIN PATHWAY
  申请人：Moon Randall T.

  公开号：US20120040916A1

  公开（公告）日：2012-02-16

  The present invention is directed toward a method of treating a subject for a condition mediated by the Wnt/β-catenin pathway by selecting a subject with a condition mediated by the Wnt/β-catenin pathway and administering to the selected subject a compound selected from the group consisting of those set forth in Table 1, Table 2, and a pharmaceutically acceptable salt thereof. A method of similarly inhibiting the Wnt/β-catenin pathway in a subject is also disclosed.