1-(2,6-Diaminopyrimidin-4-yl)oxypropan-2-yloxymethylphosphonic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 1-(2,6-Diaminopyrimidin-4-yl)oxypropan-2-yloxymethylphosphonic acid
• 化学式: C₈H₁₅N₄O₅P
• 分子量: 278.2
• InChiKey: XAPMDHJOWAAMOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Novel compounds and methods for therapy
  申请人：INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES

  公开号：US20030109499A1

  公开（公告）日：2003-06-12

  Novel compounds are provided having formula (I) 1 where R 1 , R 2 , R 3 , R 4 , Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

  提供具有以下化学式（I）的新化合物： 其中 R 1 ，R 2 ，R 3 ，R 4 ，Z，X和*在此处定义。还提供了用于抗病毒方法和合成化合物（I）的过程。
• Use of 7h-pyrrollo{2,3-d}pyrimidine derivatives in the treatment of solid tumor diseases
  申请人：Ball Ashley Howard

  公开号：US20050038048A1

  公开（公告）日：2005-02-17

  Patients suffering from a solid tumor disease selected from carcinoma of the bladder, renal carcinoma, squamous cell carcinoma of the skin, head and neck cancer, especially squamous cell head and neck cancer, lung cancer, especially non small cell lung cancer (NSCLC), tumors of the gastrointestinal tract, glioma and mesothelioma or metastases of such solid tumor diseases are treated with a 7H-pyrrolo[2,3-d]pyrimidine derivative.

  患有固体肿瘤疾病的患者，包括膀胱癌、肾癌、皮肤鳞状细胞癌、头颈癌（特别是鳞状细胞头颈癌）、肺癌（特别是非小细胞肺癌NSCLC）、消化道肿瘤、胶质瘤和间皮瘤或此类固体肿瘤疾病的转移病人，可以使用7H-吡咯并[2,3-d]嘧啶衍生物进行治疗。
• 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY
  申请人：INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

  公开号：EP1406911B1

  公开（公告）日：2016-01-06
• 6-[2-(PHOSPHONOMETHOXY)ALKOXY]PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY
  申请人：INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRYOF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

  公开号：EP1406911A1

  公开（公告）日：2004-04-14
• US6818633B2
  申请人：——

  公开号：US6818633B2

  公开（公告）日：2004-11-16