DTPA-cs124

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DTPA-cs124
• 英文别名: 2-[2-[bis(carboxymethyl)amino]ethyl-[2-[carboxymethyl-[2-[(4-methyl-2-oxo-1H-quinolin-7-yl)amino]-2-oxoethyl]amino]ethyl]amino]acetic acid
• 化学式: C₂₄H₃₁N₅O₁₀
• 分子量: 549.538
• InChiKey: HOLHLMRMKFDGMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.9
• 重原子数：
  39
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  217
• 氢给体数：
  6
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  二亚乙基三胺五乙酸二酐 、 喹诺酮 124 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以65%的产率得到DTPA-cs124
  参考文献：
  名称：

  敏化的发光ter纳米粒子：DNA的制备和时间分辨荧光测定。

  摘要：

  基于染料分子的敏化，制备了高发光度的nano纳米粒子作为生物标记。包含在颗粒中的发光络合物由作为光能传递供体的喹诺酮类染料分子和水溶性优异且对镧系元素的结合常数高的基于聚氨基羧酸盐的螯合剂组成。单分子中两个功能实体的结构使该复合物在水溶液中具有高发光性。通过反向微乳液法制备了含有ter配合物的二氧化硅纳米粒子。这种a纳米粒子的亮度与大约340种游离ter络合物一样明亮，并且具有1.5毫秒的荧光寿命，使其可以用于时间分辨荧光测定中。制备了纳米颗粒与寡核苷酸的缀合物，并用于基于磁性微珠作为固相载体的DNA夹心杂交测定。实验结果表明，纳米颗粒的检测灵敏度是染料异硫氰酸荧光素（FITC）分子的100倍以上。

  DOI：

  10.1021/ac061477h

文献信息

• Sensitized Luminescent Terbium Nanoparticles:  Preparation and Time-Resolved Fluorescence Assay for DNA
  作者：Yang Chen、Yumei Chi、Hongmei Wen、Zuhong Lu

  DOI：10.1021/ac061477h

  日期：2007.2.1

  containing terbium complexes were prepared by the reverse microemulsion method. Such a terbium nanoparticle is as bright as about 340 free terbium complexes, and it has a 1.5-ms fluorescence lifetime that enables it to be used in the time-resolved fluorescence assays. The conjugate of the nanoparticle with oligonucleotide was prepared and used to carry out a DNA sandwich hybridization assay based on

  基于染料分子的敏化，制备了高发光度的nano纳米粒子作为生物标记。包含在颗粒中的发光络合物由作为光能传递供体的喹诺酮类染料分子和水溶性优异且对镧系元素的结合常数高的基于聚氨基羧酸盐的螯合剂组成。单分子中两个功能实体的结构使该复合物在水溶液中具有高发光性。通过反向微乳液法制备了含有ter配合物的二氧化硅纳米粒子。这种a纳米粒子的亮度与大约340种游离ter络合物一样明亮，并且具有1.5毫秒的荧光寿命，使其可以用于时间分辨荧光测定中。制备了纳米颗粒与寡核苷酸的缀合物，并用于基于磁性微珠作为固相载体的DNA夹心杂交测定。实验结果表明，纳米颗粒的检测灵敏度是染料异硫氰酸荧光素（FITC）分子的100倍以上。
• Novel fine fluorescent particle
  申请人：Matsumoto Kazuko

  公开号：US20070026407A1

  公开（公告）日：2007-02-01

  Novel silica particles having bondable functional groups on the surface thereof and containing a fluorescent rare-earth complex characterized by being uninfluenced by the surrounding environment including a buffer and a substance to be labeled. The silica particles containing a fluorescent rare-earth complex specifically are ones which comprise silica particles containing a fluorescent rare-earth complex selectively in an inner layer thereof and the surface of which consists substantially of silica. Also provided are: a fluorescent labeling agent comprising the silica particles; a method of fluorescent labeling which comprises using the silica particles as a labeling agent; and a method for fluorescent determination and a reagent for fluorescent determination which employ the fluorescent labeling agent.
• US7297690B2
  申请人：——

  公开号：US7297690B2

  公开（公告）日：2007-11-20
• Triple-Emitting Dumbbell Fluorescent Nanoprobe for Multicolor Detection and Imaging Applications
  作者：Jing Liu、Jian Liu、Weisheng Liu、Haoli Zhang、Zhengyin Yang、Baodui Wang、Fengjuan Chen、Haotai Chen

  DOI：10.1021/acs.inorgchem.5b00610

  日期：2015.8.17

  The combination of different fluorescent species into one nanostructure to develop fluorescent nanoparticles with multiple emission signatures by a single wavelength excitation has become a very popular research area in the field of multiplex bioanalysis, diagnostics, and multicolor imaging. However, these novel hybrids must be elaborately designed to ensure that the unique properties of each component are conveyed, i.e., fluorescent species and nanoparticles, and are maximized without serious interactions with each other. Herein, a first triple-fluorescence dumbbell nanoprobe with large Stokes shift based on incorporating fluorescein isothiocyanate (FITC) and lanthanide complexes onto Au-Fe3O4 NPs was synthesized. This hybrid displays well-resolved triple fluorescence emission, with FITC at 515 nm, Tb(III) complex at 545 nm, and Eu(III) complex at 616 run under a single-excitation wavelength and is used for highly selective and sensitive colorimetric detection of Cu2+ with a detection limit of 30 nM. Under different Cu2+ concentrations, this hybrid exhibited distinguishable multiple colors under UV light, and the color could change in the presence of different concentrations of Cu2+. This sensor for ratio/multianalyte microscopic imaging of Cu2+ in HeLa cells and BHK cells was also demonstrated. Target molecules, such as folic acid, can be covalently attached to the fluorescent nanoparticle surface to serve as an effective probe for simultaneous multicolor imaging folate receptor-overexpressing HeLa cell lines in vitro.