di-tert-butyl 3,5,11,13-tetraoxopentadaca-1,15-dioate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: di-tert-butyl 3,5,11,13-tetraoxopentadaca-1,15-dioate
• 英文别名: Ditert-butyl 3,5,11,13-tetraoxopentadecanedioate
• 化学式: C₂₃H₃₆O₈
• 分子量: 440.534
• InChiKey: QPTVZUKKPFFENI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  31
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  庚二酸 在 正丁基锂 、 草酰氯 、 sodium hydride 、 三乙胺 作用下， 反应 1.83h， 生成 di-tert-butyl 3,5,11,13-tetraoxopentadaca-1,15-dioate
  参考文献：
  名称：

  N-acyl aziridines - C-acylating agents for the preparation of polyketides

  摘要：

  A one-pot synthesis of N-acylaziridines from carboxylic acids has been developed, and their reaction with dianions derived from beta-ketoesters studied. The aziridines were found to be efficient C-acylating agents, giving polyketide-like products in good overall yields.

  DOI：

  10.1016/s0040-4039(00)73323-5

文献信息

• N-Acyl-2-methylaziridines: Synthesis and utility in the C-acylation of β-ketoester derived dianions
  作者：Barry Lygo

  DOI：10.1016/0040-4020(95)00820-x

  日期：1995.11

  A “one pot” method for the preparation of N-acyl-2-methylaziridines is described, and the utility of these compounds in the C-acylation of dianions derived from β-ketoesters investigated. Application of this methodology to the synthesis of the polyketide natural product yangonin is also described.

  描述了用于制备N-酰基-2-甲基氮丙啶的“一锅法”，并且研究了这些化合物在衍生自β-酮酸酯的二价阴离子的C-酰化中的用途。还描述了该方法在聚酮化合物天然产物仰光宁合成中的应用。
• Barry Lygo, Tetrahedron Lett, 35 (1994) N 28, S 5073-5074
  作者：Barry Lygo

  DOI：——

  日期：——
• N-acyl aziridines - C-acylating agents for the preparation of polyketides
  作者：Barry Lygo

  DOI：10.1016/s0040-4039(00)73323-5

  日期：1994.7

  A one-pot synthesis of N-acylaziridines from carboxylic acids has been developed, and their reaction with dianions derived from beta-ketoesters studied. The aziridines were found to be efficient C-acylating agents, giving polyketide-like products in good overall yields.