N-((5-chloro-1H-indol-3-yl)methyl)(3,4,5-trimethoxyphenyl)methanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-((5-chloro-1H-indol-3-yl)methyl)(3,4,5-trimethoxyphenyl)methanamine
• 英文别名: N-[(5-chloro-1H-indol-3-yl)methyl]-1-(3,4,5-trimethoxyphenyl)methanamine
• 化学式: C₁₉H₂₁ClN₂O₃
• 分子量: 360.84
• InChiKey: GMTODAIYPYVYAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苄胺 、 5-氯吲哚-3-甲醛 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以43%的产率得到N-((5-chloro-1H-indol-3-yl)methyl)(3,4,5-trimethoxyphenyl)methanamine
  参考文献：
  名称：

  3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers

  摘要：

  T- and N-type calcium channels have known for relating to therapy of neuropathic pain which is chronic, debilitating pain state. Neuropathic pain is caused by damage of the somatosensory system. It may be associated with abnormal sensations and pain produced by normally non-painful stimuli (allodynia). Neuropathic pain is very difficult to treat, and only some 40-60% of patients achieve partial relief. For a neuropathic pain therapy, anticonvulsant like Lamotrigine, Carbamazepine and a topical anesthetic such as Lidocaine are used. We synthesized 15 novel amine derivatives and evaluated their activities against T-type and N-type calcium channels by whole-cell patch clamp recording on HEK293 cells. Among the tested compounds, compound 10 showed good inhibitory activity for both T-type and N-type calcium channels with the IC50 value of 1.9 mu M and 4.3 mu M, respectively. Compound 10 also showed good analgesic activity on rat spinal cord injury model. (c) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.07.067

文献信息

• 3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers
  作者：Bohee Kang、Jung Ae Oh、Jee Youn Lee、Hyewhon Rhim、Tae Young Yune、Hea-Young Park Choo

  DOI：10.1016/j.bmc.2015.07.067

  日期：2015.9

  T- and N-type calcium channels have known for relating to therapy of neuropathic pain which is chronic, debilitating pain state. Neuropathic pain is caused by damage of the somatosensory system. It may be associated with abnormal sensations and pain produced by normally non-painful stimuli (allodynia). Neuropathic pain is very difficult to treat, and only some 40-60% of patients achieve partial relief. For a neuropathic pain therapy, anticonvulsant like Lamotrigine, Carbamazepine and a topical anesthetic such as Lidocaine are used. We synthesized 15 novel amine derivatives and evaluated their activities against T-type and N-type calcium channels by whole-cell patch clamp recording on HEK293 cells. Among the tested compounds, compound 10 showed good inhibitory activity for both T-type and N-type calcium channels with the IC50 value of 1.9 mu M and 4.3 mu M, respectively. Compound 10 also showed good analgesic activity on rat spinal cord injury model. (c) 2015 Elsevier Ltd. All rights reserved.