吡啶联氮基[4,5-c]哒嗪-3,4-二羧酸,1,4,5,6-四氢-1-甲基-5-羰基-6-(苯基甲基)-,二甲基酯 | 128457-04-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 吡啶联氮基[4,5-c]哒嗪-3,4-二羧酸,1,4,5,6-四氢-1-甲基-5-羰基-6-(苯基甲基)-,二甲基酯
• 英文名称: dimethyl 6-benzyl-1-methyl-5-oxo-4H-pyridazino[3,4-d]pyridazine-3,4-dicarboxylate
• CAS: 128457-04-5
• 化学式: C₁₈H₁₈N₄O₅
• 分子量: 370.365
• InChiKey: IWGRSVSOWNPDAJ-UHFFFAOYSA-N

物化性质

• 熔点：
  97-98 °C
• 沸点：
  509.6±60.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-苄基-4,5-二溴吡嗪-3(2H)-酮 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 吡啶联氮基[4,5-c]哒嗪-3,4-二羧酸,1,4,5,6-四氢-1-甲基-5-羰基-6-(苯基甲基)-,二甲基酯
  参考文献：
  名称：

  Yamasaki, Tetsuo; Kawaminami, Eiji; Yamada, Tomomi, Journal of the Chemical Society. Perkin transactions I, 1991, # 5, p. 991 - 996

  摘要：

  DOI：

文献信息

• Novel cyclization and rearrangement to 1,4-dihydropyridazino[4,5-c]pyridazinones
  作者：Tetsuo Yamasaki、Eiji Kawaminami、Tomomi Yamada、Tadashi Okawara、Mitsuru Furukawa

  DOI：10.1039/c39900000645

  日期：——

  1,4-Dihydropyridazino[4,5-c]pyridazinones were prepared by a novel one-pot cyclization and dehydrogenation from hydrazinopyridazinones and dimethyl acetylenedicarboxylate.

  1，4-二氢吡啶并[4,5- c ]吡啶并酮是通过新颖的一锅环化反应从肼基并吡嗪酮和乙酰二羧酸二甲酯制备的。
• Interleukin-1 blocker for use in the treatment of age-related macular degeneration
  申请人：THE TEXAS A & M UNIVERSITY SYSTEM

  公开号：EP2508183A1

  公开（公告）日：2012-10-10

  The present invention relates to a composition for use in the treatment of age-related macular degeneration comprising an interleukin-1 blocker.

  本发明涉及一种用于治疗老年性黄斑变性的组合物，其中包含一种白细胞介素-1阻断剂。
• YAMASAKI, TETSUO;KAWAMINAMI, EIJI;YAMADA, TOMOMI;OKAWARA, TADASHI;FURUKAW+, J. CHEM. SOC. CHEM. COMMUN. ,(1990) N, C. 645-647
  作者：YAMASAKI, TETSUO、KAWAMINAMI, EIJI、YAMADA, TOMOMI、OKAWARA, TADASHI、FURUKAW+

  DOI：——

  日期：——
• Therapeutic Compositions And Methods
  申请人：Chiou George C.

  公开号：US20120071485A1

  公开（公告）日：2012-03-22

  The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision.
• THERAPEUTIC COMPOSITIONS AND METHODS
  申请人：CHIOU GEORGE C.

  公开号：US20120196868A1

  公开（公告）日：2012-08-02

  The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision.