4-(1-(2-hydroxyphenyl)ethoxy)butan-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1-(2-hydroxyphenyl)ethoxy)butan-2-one
• 英文别名: 4-[1-(2-Hydroxyphenyl)ethoxy]butan-2-one；4-[1-(2-hydroxyphenyl)ethoxy]butan-2-one
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: IPLFHZATZVAOJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻甲基苄醇 在 Pd((-)-sparteine)2Cl₂ air 、 苏合香醇 、 potassium tert-butylate 、 copper dichloride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 64.0h， 生成 4-(1-(2-hydroxyphenyl)ethoxy)butan-2-one
  参考文献：
  名称：

  Development of a General Pd(II)-Catalyzed Intermolecular Hydroalkoxylation Reaction of Vinylphenols by Using a Sacrificial Alcohol as the Hydride Source

  摘要：

  A general hydroalkoxylation of vinylphenols has been successfully developed wherein primary, secondary, and tertiary alcohols can be used as nucleophiles. The key conceptual breakthrough is the use of sec-phenethyl alcohol at relatively low concentrations as the sacrificial alcohol to undergo oxidation and provide the proposed Pd-H intermediate.

  DOI：

  10.1021/ol062222t

文献信息

• Development of a General Pd(II)-Catalyzed Intermolecular Hydroalkoxylation Reaction of Vinylphenols by Using a Sacrificial Alcohol as the Hydride Source
  作者：Yang Zhang、Matthew S. Sigman

  DOI：10.1021/ol062222t

  日期：2006.11.1

  A general hydroalkoxylation of vinylphenols has been successfully developed wherein primary, secondary, and tertiary alcohols can be used as nucleophiles. The key conceptual breakthrough is the use of sec-phenethyl alcohol at relatively low concentrations as the sacrificial alcohol to undergo oxidation and provide the proposed Pd-H intermediate.