2-methyl-5-oxohexanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyl-5-oxohexanoic acid
• 英文别名: (2R)-2-methyl-5-oxohexanoic acid
• 化学式: C₇H₁₂O₃
• 分子量: 144.17
• InChiKey: RJKCQJNOJDMYEM-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (R)-2-甲基-5-氧代己醛 在 sodium dichromate 、 硫酸 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 2-methyl-5-oxohexanoic acid
  参考文献：
  名称：

  二苯基脯氨醇甲醚：一种高对映选择性的催化剂，用于将醛迈克尔加成为简单的烯酮。

  摘要：

  [反应：见正文]二苯基脯氨醇甲醚催化简单的分子间迈克尔加成到相对未活化的烯酮上，迄今为止报道的对映选择性最高（95-99％ee），并且催化剂的负载量大大低于该领域的典型水平。

  DOI：

  10.1021/ol0517729

文献信息

• AMINOTHIAZOLES AND THEIR USES
  申请人：Bushell Simon

  公开号：US20140315790A1

  公开（公告）日：2014-10-23

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

  本申请描述了对治疗、预防和/或改善疾病有用的有机化合物。
• Enantioselective Organocatalytic Michael Additions of Aldehydes to Enones with Imidazolidinones:  Cocatalyst Effects and Evidence for an Enamine Intermediate
  作者：Timothy J. Peelen、Yonggui Chi、Samuel H. Gellman

  DOI：10.1021/ja0532584

  日期：2005.8.24

  An enantioselective intermolecular Michael addition of aldehydes to enones catalyzed by imidazolidinones has been achieved. Chemoselectivity (Michael addition vs aldol) can be controlled through judicious choice of hydrogen-bond-donating cocatalysts. The optimal imidazolidinone/hydrogen-bond-donor pair affords Michael addition products in excess of 90% ee. Furthermore, we have isolated and characterized

  已经实现了醛与由咪唑烷酮催化的烯酮的对映选择性分子间迈克尔加成。化学选择性（迈克尔加成与羟醛）可以通过明智地选择供氢键的助催化剂来控制。最佳咪唑烷酮/氢键供体对提供超过 90% ee 的迈克尔加成产物。此外，我们已经分离并表征了烯胺中间体，并证明了其在观察到的迈克尔加成反应中作为亲核试剂的功效。
• INHIBITORS OF POLO-LIKE KINASE
  申请人：Galemmo Robert A.

  公开号：US20110207716A1

  公开（公告）日：2011-08-25

  The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E 1 , E 2 , R 1 , R 2 , R 3 and R 4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

  本发明提供了具有以下结构的化合物（I）的盐或溶剂，其中环A、E1、E2、R1、R2、R3和R4在此定义。本发明还提供了包括本发明化合物的制药组合物以及使用本发明化合物和组合物的方法，例如在治疗和预防各种疾病，如帕金森病方面的应用。
• Janadolide, a Cyclic Polyketide–Peptide Hybrid Possessing a <i>tert</i>-Butyl Group from an <i>Okeania</i> sp. Marine Cyanobacterium
  作者：Hidetoshi Ogawa、Arihiro Iwasaki、Shinpei Sumimoto、Yuki Kanamori、Osamu Ohno、Masato Iwatsuki、Aki Ishiyama、Rei Hokari、Kazuhiko Otoguro、Satoshi O̅mura、Kiyotake Suenaga

  DOI：10.1021/acs.jnatprod.6b00171

  日期：2016.7.22

  Janadolide, a new cyclic polyketide peptide hybrid possessing a tert-butyl group, was isolated from an Okeania sp. marine cyanobacterium. The gross structure was elucidated by spectroscopic analyses, and the absolute configurations of the amino acid moieties were determined by acid hydrolysis and chiral-phase HPLC analyses. The absolute configuration of the two stereogenic centers in the polyketide moiety was elucidated based on a combination of degradation reactions and spectroscopic analyses including the phenyl-glycine methyl ester method. Janadolide showed potent antitrypanosomal activity with an IC50 value of 47 nM without cytotoxicity against human cells at 10 mu M.
• AMINOTHIAZOLE DERIVATIVES AND THEIR USES AS ANTIBACTERIAL AGENTS
  申请人：Novartis AG

  公开号：EP2044101B1

  公开（公告）日：2013-10-09