吲哚-3-甲胺 | 82923-81-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 吲哚-3-甲胺
• 中文别名: (S)-吲哚啉-2-甲酸乙酯；(S)-吲哚啉-2-羧酸乙酯；2-甲酸乙酯吲哚啉
• 英文名称: (S)-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester
• 英文别名: indoline-2-carboxylic acid ethyl ester；(S)-ethyl indoline-2-carboxylate；ethyl (S)-2-indoline carboxylate；ethyl (S)-indoline-2-carboxylate；(S)-2,3-dihydro-1H-indole-2-carboxylic acid, ethyl ester；indoline-2S-carboxylic acid ethyl ester；(S)-Indoline-2-carboxylic acid ethyl ester；ethyl (2S)-2,3-dihydro-1H-indole-2-carboxylate
• CAS: 82923-81-7
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: KISPUTPAKVZNBI-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  吲哚-3-甲胺 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以68%的产率得到(S)-(+)-二氢吲哚-2-甲醇
  参考文献：
  名称：

  Synthesis of Novel (3a,S)‐1‐Aryl/aryloxy/alkoxy‐3a,4‐dihydro‐3H‐1λ⁵‐[1,3,2]oxazaphospholo [3,4‐a] indole‐1‐ones, Thiones, and Selenones

  摘要：

  Synthesis of novel (3a,S)-1-aryl/aryloxy/alkoxy-3a,4-dihydro-3H-1 lambda(5)-[1,3,2]oxazaphospholo [3,4-a] indole-1-ones, thiones, and selenones was achieved in two steps with high yields from 2,3-dihydro-1H-indol-2(S)yl methanol (1) and dichlorophenyl phosphine/ethyl dichlorophosphite (2a and b) in the presence of triethylamine in dry THF followed by treatment with hydrogen peroxide, sulfur, and selenium. The compounds 4g-k have been synthesized by the direct cyclocondensation of 1 with different substituted phenyl phosphorodichloridates (2c-e, g) and bis(2-chloroethyl) phosphoramidic dichloride (2f).

  DOI：

  10.1080/00397910801914236
• 作为产物：
  描述：

  (S)-吲哚啉-2-羧酸 生成 吲哚-3-甲胺
  参考文献：
  名称：

  GRUENFELD, N.

  摘要：

  DOI：

文献信息

• [EN] COSMETIC USES AND METHODS FOR INDOLINE GRANZYME B INHIBITOR COMPOSITIONS<br/>[FR] UTILISATIONS ET PROCÉDÉS COSMÉTIQUES POUR DES COMPOSITIONS D'INHIBITEUR D'INDOLINE GRANZYME B
  申请人：VIDA THERAPEUTICS INC

  公开号：WO2014153667A1

  公开（公告）日：2014-10-02

  Cosmetic uses and methods for indoline granzyme B inhibitor compounds in compositions with a cosmetically acceptable carrier. Uses and methods for treating, reducing or inhibiting the appearance of ageing in the skin are provided. Also provided are compositions and formulation for cosmetic uses and methods of maintaining a youthful appearance, reducing an appearance of ageing, inhibiting an appearance of ageing, reducing a rate of an appearance of ageing, reducing a skin inelasticity, reducing a rate of increasing skin inelasticity, maintaining a skin elasticity, and increasing the density of hair follicles of a skin of a subjecl. The uses and methods comprise applying/administering an indoline granzyme B inhibitor to a skin, or a portion of a skin of the subject.

  使用和方法用于在与化妆品可接受载体混合的化合物中使用吲哚啶颗粒酶B抑制剂。提供了用于治疗、减少或抑制皮肤衰老的用途和方法。还提供了用于化妆品用途的组合物和配方，以及保持年轻外观、减少衰老外观、抑制衰老外观、减少衰老外观速率、减少皮肤无弹性、减少增加皮肤无弹性速率、保持皮肤弹性和增加皮肤毛囊密度的方法。这些用途和方法包括将吲哚啶颗粒酶B抑制剂涂抹/施用于皮肤或受试者皮肤的部分。
• C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases
  申请人：——

  公开号：US20020042376A1

  公开（公告）日：2002-04-11

  This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

  这项发明涉及新型的oxamyl二肽ICE/ced-3家族抑制剂化合物。该发明还涉及含有这些化合物的药物组合物，以及在治疗患有炎症性、自身免疫和神经退行性疾病的患者中使用这些组合物，用于预防缺血性损伤，并用于保存即将进行移植手术的器官。
• 1-mercaptoalkanoylindoline-2-carboxylic acids
  申请人：Ciba-Geigy Corporation

  公开号：US04599357A1

  公开（公告）日：1986-07-08

  1-Mercaptoalkanoylindoline-2-carboxylic acids, e.g., those of the formula ##STR1## and functional derivatives thereof, are antihypertensive and cardioactive agents.

  1-巯基烷酰吲哚-2-羧酸，例如，具有公式##STR1##的化合物及其功能性衍生物，是抗高血压和心脏活性剂。
• New β‐Amino Alcohols as Chiral Ligands for the Catalytic Enantioselective Reduction of Prochiral Ketones and the Nucleophilic Addition of Diethylzinc to Benzaldehyde
  作者：Viola Peper、Jürgen Martens

  DOI：10.1002/cber.19961290616

  日期：1996.6

  New optically active β-amino alcohols, derived from various acyclic and cyclic amino acids with alkyl groups on the carbinol carbon atom, were used in the enantioselective reduction of prochiral ketones. The attachment of alkyl groups to the nitrogen atom of the catalyst (R)-1b was shown to influence favorably the enantioselectivity of the addition of diethylzinc to benzaldehyde. In both cases the

  衍生自在甲醇碳原子上具有烷基的各种无环和环状氨基酸衍生的新型旋光性β-氨基醇用于前手性酮的对映选择性还原。烷基与催化剂（R）-1b的氮原子的连接显示出有利地影响了将二乙基锌添加至苯甲醛的对映选择性。在两种情况下，都以中等至高的光学收率获得了所得的仲醇。
• Compounds for inhibiting &bgr;-amyloid peptide release and/or its synthesis
  申请人：Elan Pharmaceuticals, Inc.

  公开号：US06211235B1

  公开（公告）日：2001-04-03

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.

  揭示了一种抑制β-淀粉样肽释放和/或其合成的化合物，因此在治疗阿尔茨海默病方面具有用途。还揭示了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物。